Bacterial Endotoxin Limit (EL) is defined as EL=K/m, where K=5 Endotoxin Units (EU) kg of the body weight or 5 EU/kg/hr;m= maximun bolus dose of a product, and the average human body weight is 70kg.The maximun Valid Dilution (MVD) of a product is equal to (EL x Concentration of the product)/sensivity of the lysate

Find the EL for a product whose maximun pediatric dose is 4 mg/ml/kg and concentration is 20mg/ml. Expressthe EL in EU/ml and EU/mg

If the sensivitty of the lysate is EU/ml, the Endotoxin soecification per monograph is EU/mg, the maximun bolus dose is 1ug/kg/min and the concentration is 0.2mg/ml.CAn the monograph specification be used as the Endotoxin limit? Explain

Calculate the MVD based on problem #2

Explain the way of action of antibiotics known as aminoglycosides, tetracyclines and macrolides. Give detailed answer.

Insulin-like growth factor 2 receptor (Igf2r) gene is expressed exclusively from the maternal allele on chromosome 17 due to

A. differential methylation of an Igf2r intron.

B. differential expression of an antisense RNA transcript.

C. transposition of the maternal copy of Igf2r.

D. methylation of an imprinting control region.

1. Define the following terms: allele, incomplete dominance, codominance, pleiotropy, epistasis. What are some examples of each?

18. Entamoeba histolytica is the causative organism in amoebic dysentery. This organism is a(n)
       Protozoan
       Bacterium
       Fungus
       Virus

20. Antibiotic-induced diarrhea is most often caused by an overgrowth of this specific bacterium:
       Clostridium difficile
       Clostridium perfringens
       Candida albicans
       Yersinia pestis

22. Acute glomerulonephritis is a late-developing consequence of which of the following diseases?
       Streptococcal pharyngitis (strep throat)
       Influenza
       Rhinosinusitis
       Pneumonia

31. The opportunistic pathogen often responsible for causing necrotizing fasciitis (also known as the "flesh-eating bacteria") in healthy young adults is called:
       Staphylococcus epidermis
       Streptococcus pyogenes
       Bacillus subtilis
       Streptococcus pneumoniae

what is sex

Describe the structure of the cell envelope of a gram-positive bacteria and compare it with that of a gram-negative bacteria. Give detailed answer.

Describe the start of transcription in bacteria and the function of the sigma factor. Give detailed answer.

As we try to define life, we believe that O₂, which is so pervasive in the environment, is fundamentally necessary to sustain life.  Clostridium & Streptococcus are both catalase-negative bacteria, but only Streptococcus grows by fermentation. Why then is Clostridium killed by O₂, whereas Streptococcus is not?

Respond to the following in a minimum of 300 words:

Is radiation of species static or ongoing? Explain.

Debate the efficacies of public versus private-based quality initiatives. What roles do each play in the quality of U.S. health care? How would the elimination of one aspect affect the other? Respond to two other classmates and counter their answer

Lamarck, in part, based his erroneous theory of evolution on the passing of acquired characteristics from one generation to the next. Darwin’s theory is based on the passing of inherited genetic characteristics from one generation to the next. Determine which of the characteristics listed below are acquired, inherited or involve both acquired and inherited

Explain your choices.

1. Increased proficiency in playing the clarinet: acquired or inherited or both

2. Thick subcutaneous fat layer in arctic seals: acquired or inherited or both

3. Attaining a height of two meters in humans: acquired or inherited or both

4. Grizzly bears hibernating during the winter: acquired or inherited or both

1. Which of the following groups of allosteric effectors are all sensors of an energy poor status in the cell?

Group of answer choices

a.cAMP, CoASH, ADP

b.ATP, NADH, acetyl CoA

2. Which one of the following statements about gluconeogenesis in mammals is false?

a.It consists entirely of the reactions of glycolysis, operating in the reverse direction.

b.It requires metabolic energy (ATP or GTP).

c. It can use amino acids as starting material.

d. The pathway includes the liver enzyme glucose-6-phosphatase.

3. Which of the following is true of mammalian glycogen synthase?

It catalyzes addition of (α1 ⟶⟶ 4) linked glucose residues to the nonreducing end of a glycogen chain.

PKA activation of glycogen synthase requires phosphorylation of one or more amino acids.

The enzyme binds F2,6 bisphosphate (F26BP).

cAMP is an allosteric effector that binds and inhibits glycogen synthase.

c.AMP, NAD+, CoASH

d. Acetyl CoA, AMP, NAD+

4. If a cell is actively fluxing only phases I (oxidative) and II (isomerase) of the pentose phosphate pathway, which of the following statement most accurately describes the physiological status of the cell from the information given?

The cell is in an energy-poor status.

The cell is at the point in its cell cycle where DNA replication is highest.

The cell is under oxidative stress and needs high level of glucose.

The cell is producing heat through uncoupled electron flow.

5.

Which of the following is true about F26BP (fructose-2,6bisphosphate)?

Its level is regulated by glucagon in the mammalian liver.

It is synthesized and broken down by a bifunctional enzyme.

It is not an intermediate in any metabolic pathway.

All statements about F26BP are true.