Insulin-like growth factor 2 receptor (Igf2r) gene is expressed exclusively from the maternal allele on chromosome...

Insulin-like growth factor 2 receptor (Igf2r) gene is expressed exclusively from the maternal allele on chromosome 17 due to

A. differential methylation of an Igf2r intron.

B. differential expression of an antisense RNA transcript.

C. transposition of the maternal copy of Igf2r.

D. methylation of an imprinting control region.

Expert Solution

Answer ) A. differential methylation of an Igf2r intron.

EXPLANATION

Genomic imprinting is a phenomenon characterized by parent-of-origin-specific expression. The imprint is a mark established during germ-cell development to distinguish between the paternal and maternal copies of the imprinted genes.

The insulin-like growth factor II receptor (Igf2r), also known as the cation-independent mannose-6-phosphate receptor, which is present on the 17 chromosome. The maternal allele is expressed exclusively while paternally derived allele is inactive.

Two regions of the mouse Igf2r gene are differentially methylated on the parental chromosomes thus serve as epigenetic marks regulating genomic imprinting .

The first region includes the Igf2r promoter and is methylated only on the suppressed paternal allele.
The other modified region is located in intron 2 of Igf2r, and it is preferentially methylated on the expressed maternal allele.

gladiator answered 1 year ago

In the lgf-2 allele, which chromosome is imprinted/silenced? Which is expressed?

23) After insulin or a growth factor such as EGF or PDGF binds to its receptor...

23) After insulin or a growth factor such as EGF or PDGF binds to its receptor and the receptors form a dimer, what is the next immediate event? a. Adaptor proteins binds to the receptor due to a conformational change. b. The dimerized receptor acts as a kinase to phosphorylate one or more tyrosine residues on its dimerized partner. c. The dimerized receptor acts as a kinase yo phosphorylate one or more serine or threonine residues on its dimerized partner....

The normal chemokine receptor 5 gene (CCR5) allele “+” and a variant allele D was found...

The normal chemokine receptor 5 gene (CCR5) allele “+” and a variant allele D was found in a population of people. The variant D has a deletion of 32 base pairs called “Delta 32”. A sample of people from this population were tested for the variation in the CCR5 gene. The researchers found 16 people were homozygous for Delta 32; 165 people were heterozygous for the Delta 32 deletion; 433 people did not have the Delta 32 deletion. Choose all...

Bio 101 Mitosis Lab What are the definitions of the following terms: DNA: Chromosome: Gene: Allele:...

Bio 101 Mitosis Lab What are the definitions of the following terms: DNA: Chromosome: Gene: Allele: Locus:

Question 2 (5 pts). In roses, two gene loci on an autosomal chromosome are 30cM from...

Question 2 (5 pts). In roses, two gene loci on an autosomal chromosome are 30cM from each other. At locus 1, the E allele for red flower color is completely dominant to the e allele for pink flower color. At locus 2, the G allele for thorns is completely dominant to allele g for thornless. A particular rose cultivar, true-breeding for red flower and thorns, is crossed to cultivar 2, true-breeding for pink flowers and thornless. The F1 generation is...

1. What determines whether a gene allele is a risk-increasing versus a risk-decreasing allele? 2. What...

1. What determines whether a gene allele is a risk-increasing versus a risk-decreasing allele? 2. What does it mean when we say that genetic factors influence what dose of a drug will be safest and most effective for you? 3. Imagine someone who has asthma has a direct-to-consumer test that tells him that he has risk- decreasing alleles for asthma in two of his relevant genes. How do you explain the fact that he has asthma, despite having two risk-decreasing...

Genes A and B are located 10cM from each other on a chromosome. Gene C is...

Genes A and B are located 10cM from each other on a chromosome. Gene C is located 25cM from gene A and 15cM from gene B. Assuming that I = 0, what is the probability that the trihybrid ABC/abc will produce an ABC gamete? I get that ABC is a result of a double crossover. A similar question was answered and said that Probability of SCO - DCO = 0.25 - 0.015 = 0.235 PLEASE EXPLAIN HOW YOU GET .25...

Members of the epidermal growth factor receptor tyrosine kinase (RTK) family (EGFR/ERBB1, ERBB2/HER2, ERBB3/HER3 and ERBB4/HER4)...

Members of the epidermal growth factor receptor tyrosine kinase (RTK) family (EGFR/ERBB1, ERBB2/HER2, ERBB3/HER3 and ERBB4/HER4) are key targets for inhibition in cancer therapy. Critical for activation is the formation of a dimer in the cytoplasmic domain that induces autophosphorylation on specific tyrosine residues. A cytoplasmic protein, called MIG6, interacts with the cytoplasmic domains of RTKs and inhibits their kinase domain. Based on your knowledge of RTK signaling, what effect would you expect MIG6 overexpression in cancer cells to have...

1. DISCUSS THE ROLE OF EGF(Epidermal Growth Factor) IN STEROIDOGENESIS 2. DISCUSS THE ROLE OF StAR IN STEROIDOGENESIS...

1. DISCUSS THE ROLE OF EGF(Epidermal Growth Factor) IN STEROIDOGENESIS 2. DISCUSS THE ROLE OF StAR IN STEROIDOGENESIS 3. Name 5 differences between male and female meiosis

Transcription: From DNA to RNA 1. Define a gene. 2. How does RNA differ from DNA?...

Transcription: From DNA to RNA 1. Define a gene. 2. How does RNA differ from DNA? 3. Briefly describe the process of transcription. 4. Describe the process of transcription as it occurs in prokaryotes. 5. What is the role of the promoter? 6. Describe the process of transcription as it occurs in eukaryotes. 7. What is the role of the transcription factors? A mutation exists in transcription factors that causes them to bind slightly downstream of the TATA box, causing...

Question