Biochemistry 1. what is the biochemical cause for familial hypercholestemia? 2. What enzyme is targeted by...

Biochemistry

1. what is the biochemical cause for familial hypercholestemia?

2. What enzyme is targeted by the current cholesterol lowering drugs, the stains?

3. Under roles of lipoprotein and their interactions with the intestine, adipocytes liver and peripheral tissue.

4. The largest drugs to be approved as cholesterol lowering drugs are bind irreversibly to PSSCK9 protein. Find out what the role of PCSK9 is and why inhibitors of them would lower serum cholesterol level?

In: Chemistry

There are many ongoing research projects that have been conducted that have traced the individual pathways...

There are many ongoing research projects that have been conducted that have traced the
individual pathways of nerves in the brain (where they start, where they end, and the path
taken). Considering the analogy of the nerves as highways, is this useful or not? Why?

In: Biology

Assume a mutual fund owns 2,500 shares of Goldman Sachs, trading at $66.25, 1,500 shares of...

Assume a mutual fund owns 2,500 shares of Goldman Sachs, trading at $66.25, 1,500 shares of Amazon, currently trading at $61.75, and 2,000 shares of Apple, trading at $18.50 on day 1. The mutual fund has no liabilities and 15,000 shares outstanding held by investors.

a. What is the NAV of the fund?

b. Calculate the change in the NAV of the fund if the next day Goldman Sachs’ shares increase to $69, Amazon’s shares increase to $65, and Pfizer’s shares decrease to $15.50.

c. Assume that on Day 1, 750 additional investors buy one share each of the mutual fund at the NAV obtained in part a) equal to $Y. This means that the fund manager has 750 * Y additional funds to invest. The fund manager decides to use these additional funds to buy additional shares in Amazon. Calculate next day’s NAV given the same rise in share values as calculated in part b.

In: Finance

Question 1 2C2 H4 + 02 -- > 2C2 H40 Ethylene oxide is produced by the...

Question 1

2C2 H4 + 02 -- > 2C2 H40

Ethylene oxide is produced by the catalytic oxidation of ethylene. The feed into the reactor contains 1700 g/min ethylene and 3700 moles/min air.

a.      What is the limiting reactant?

b.      What is the extent of reaction if only 81% of the limiting reactant is converted to the product?

c.       What is the molar composition of the product stream?

Question 2

Air at 95 °F can hold maximum of 3.52 wt% water, defined as 100% humidity at 95°F. On a hot humid day the temperature is 95°F and the air contains 3.2 wt% water (90.9 % humidity). The air cooled to 68 °F because air at 68 °F can hold a maxium of 1.44 wt% water ( i.e 100% humidity at 68 °F), water condenses from the air. Hot humid air (95°F, 90.9% humidity) flows into a cooler at a rate of 154 .0 Kg/min. Calculate the flow rate of 2 streams leaving the cooler:

a.      Air at 68°F and 1OO% humidity (stream 1: air leaving the cooling unit)

b.      Water condensed from the air (stream 2: water leaving the cooling unit)

c.       What is the degree of freedom for the cooling unit

Question 3

A mixture of organic solvents containing 45.0 mole o/o xylene, 25.0o/o toluene, and the balance benzene (X) is fed to a distillation column. The bottom product contains 98.0 mole% xylene and no benzene, and 96.0°/o of the xylene in the feed is recovered in this stream. The overhead product is fed to a second distillation column. The overhead product from the second column contains 97.0o/o of the benzene in the feed to this column. The composition of this stream i 94.0 mole% benzene and the balance toulene.

a)      Draw and label a flow chart for the process

b)      Calculate the unknown process variables

c)      The percentage of the benzene in the process feed (i.e. the feed to the first column) that emerge ,in the overhead product from the second column.

d)      The percentage of toluene in the process feed that emerges in the bottom product from the second column.

If anybody can solve these questions I would rally appreciate it.

In: Chemistry

The following information is available to reconcile Branch Company’s book balance of cash with its bank...

The following information is available to reconcile Branch Company’s book balance of cash with its bank statement cash balance as of July 31, 2017.

  

  1. On July 31, the company’s Cash account has a $24,752 debit balance, but its July bank statement shows a $27,080 cash balance.
  2. Check No. 3031 for $1,520 and Check No. 3040 for $752 were outstanding on the June 30 bank reconciliation. Check No. 3040 is listed with the July canceled checks, but Check No. 3031 is not. Also, Check No. 3065 for $536 and Check No. 3069 for $2,288, both written in July, are not among the canceled checks on the July 31 statement.
  3. In comparing the canceled checks on the bank statement with the entries in the accounting records, it is found that Check No. 3056 for July rent expense was correctly written and drawn for $1,280 but was erroneously entered in the accounting records as $1,270.
  4. The July bank statement shows the bank collected $7,500 cash on a noninterest-bearing note for Branch, deducted a $38 collection expense, and credited the remainder to its account. Branch had not recorded this event before receiving the statement.
  5. The bank statement shows an $805 charge for a $795 NSF check plus a $10 NSF charge. The check had been received from a customer, Evan Shaw. Branch has not yet recorded this check as NSF.
  6. The July statement shows a $11 bank service charge. It has not yet been recorded in miscellaneous expenses because no previous notification had been received.
  7. Branch’s July 31 daily cash receipts of $8,652 were placed in the bank’s night depository on that date but do not appear on the July 31 bank statement.

Required:

1.
Prepare the bank reconciliation for this company as of July 31, 2017.

2. Prepare the journal entries necessary to bring the company’s book balance of cash into conformity with the reconciled cash balance as of July 31, 2017. (If no entry is required for a transaction/event, select "No journal entry required" in the first account field.)
  

In: Accounting

1. Tuco Salamanca Corp. sold a machine for $4,000 on December 31, 2019. The machine was...

1.

Tuco Salamanca Corp. sold a machine for $4,000 on December 31, 2019. The machine was purchased on January 1, 2016, for $8,500. The residual value was estimated at $500, and the firm uses the straight-line depreciation method with an estimated useful life of 8 years. Which of the statements is correct?

a.

The company will record a gain from the sale of $500.

b.

The company will report a gain from the sale of $0.

c.

The company will record a loss from the sale of $500.

d.

The company will report a loss from the sale of $250.

2.

Which of the following costs will not be part of the value of PP&E that is constructed by a company for internal use?

a.

Wages of construction workers.

b.

Depreciation of the machines used in the construction.

c.

The salary of the CEO.

d.

Interest on debt used to finance the construction.

3.

The depreciation expense will never appear in:

a.

The notes to the financial statements.

b.

The balance sheet.

c.

The income statement.

d.

The statement of cash flows.

4.

Skinny Pete Inc. uses the units method of depreciation for one of its machines. The company bought the machine on March 12, 2017, for $1,400. The company estimates that the machine will be used to produce 300 gadgets in 2017, 500 gadgets in 2018, and 400 gadgets in 2019. The company further estimates that the machine has a residual value of $200. The machine was sold on December 31, 2018, for $600. Which of the statements is correct?

a.

The company will report a loss from the sale of $300.

b.

The company will record a gain from the sale of $333.33.

c.

The company will record a loss from the sale of $333.33.

d.

The company will report a gain from the sale of $0.

In: Accounting

A block is attached to the top of a spring that stands vertically on a table....

A block is attached to the top of a spring that stands vertically on a table. The spring stiffness is 49 N/m, its relaxed length is 27 cm, and the mass of the block is 300 g. The block is oscillating up and down as the spring stretches and compresses. At a particular time you observe that the velocity of the block is <0, 0.0877, 0> m/s and the position of the block is <0, 0.0798, 0> m relative to an origin at the base of the spring. Using a time step of 0.1 s, determine the position of the block 0.2 s later. The correct answer is .373651. How was this answer found?

In: Physics

The syntax of a language is quite simple. The alphabet of the language is {a, b,...

The syntax of a language is quite simple. The alphabet of the language is {a, b, d, #} where # stands for a space. The grammar is
<sentence> → <word> | <sentence> # <word>
<word> → <syllable> | <syllable> <word> <syllable>
<syllable> → <plosive> | <plosive> <stop> | a <plosive> | a <stop>
<plosive> → <stop> a
<stop> → b | d

Which of the following speakers is an imposter? An impostor does not follow the rules of the language.
a: ba#ababadada#bad#dabbada Chimp:

b: abdabaadab#ada
c: Baboon: dad#ad#abaadad#badadbaad

In: Computer Science

How does accounting for a nongovernmental not-for-profit organization differ from accounting for a for-profit corporation? Choose...

How does accounting for a nongovernmental not-for-profit organization differ from accounting for a for-profit corporation? Choose a not-for-profit, review its financial statements, and explain the items that you find that are different from what you would see in the financial statements of a for-profit corporation.

In: Accounting

In GoogleCollab (Python) Write a function power(x,i) that takes an int i and a float (i.e....

In GoogleCollab (Python)

  • Write a function power(x,i) that takes an int i and a float (i.e. real number) x and returns xi, do not use Python’s in-built power function x**i , instead write a loop to do so using only multiplication.
  • Now do use the power function x**i to write a second function unit_test(y) that tests whether your first function is working correctly or not.  
  • Does power(x,i) work for any value of x and i ? For which values x and i does it throw an error? What happens if the input variables are letters instead of a float and an int?
  • Write a new function power_2(x,i)so that instead of throwing an error, the function prints a message that explains what went wrong in each case?  

In: Computer Science

Never forget that even small effects can be statistically significant if the samples are large. To...

Never forget that even small effects can be statistically significant if the samples are large. To illustrate this fact, consider a sample of 129 small businesses. During a three-year period, 14 of the 100 headed by men and 5 of the 29 headed by women failed.

(a) Find the proportions of failures for businesses headed by women and businesses headed by men. These sample proportions are quite close to each other. Give the P-value for the test of the hypothesis that the same proportion of women's and men's businesses fail. (Use the two-sided alternative). What can we conclude (Use α=0.05α=0.05)?
The P-value was _______

(b) Now suppose that the same sample proportion came from a sample 30 times as large. That is, 150 out of 870 businesses headed by women and 420 out of 3000 businesses headed by men fail. Verify that the proportions of failures are exactly the same as in part (a). Repeat the test for the new data. What can we conclude?

The P-value was _______

(c) It is wise to use a confidence interval to estimate the size of an effect rather than just giving a P-value. Give 95% confidence intervals for the difference between proportions of men's and women's businesses (men minus women) that fail for the settings of both (a) and (b). (Be sure to check that the conditions are met. If the conditions aren't met for one of the intervals, use the same type of interval for both)

Interval for smaller samples: _____ to _____
Interval for larger samples: _____ to _____

In: Math

SHOW WORK FOR CALCULATIONS 1. Complete questions: Define each of the following terms: a. Operating plan;...

SHOW WORK FOR CALCULATIONS

1. Complete questions: Define each of the following terms:

a. Operating plan; financial plan

b. Spontaneous liabilities; profit margin; payout ratio

c. Additional funds needed (AFN); AFN equation; capital intensity ratio; self-supporting growth rate

d. Forecasted financial statement approach using percentage of sales e. Excess capacity; lumpy assets; economies of scale

f. Full capacity sales; target fixed assets to sales ratio; required level of fixed assets

2. Complete problem: Premium for Financial Risk XYZ, Inc. has an unlevered beta of 1.0. They are financed with 50% debt and has a levered beta of 1.6. If the risk-free rate is 5.5% and the market risk premium is 6%, how much is the additional premium that XYZ, Inc. shareholders require to be compensated for financial risk? Show your work.

In: Finance

5) Two particles are placed on the y-axis. Particle 1, with a charge of -2 C,...

5) Two particles are placed on the y-axis. Particle 1, with a charge of -2 C, is placed at (0,0) and particle 2, which has a charge of 8 C, is placed at (0, 12). The two particles are 12 m apart.

(a) Draw a diagram of the scenario above. Draw the electric field lines of each particle, as if the other particle was not present.

(b) Using the two sets of electric field lines above, draw the net electric field lines for the two particles below.

(c) Which of the following regions cannot have a location where the net field is 0 N/C? (Yes, this is a multiple choice question, but you must select all choices that apply and give a reason why those choice(s) would answer the given question.) (i) Region below of particle 1 (ii) Region between particle 1 and 2 (iii) Region above of particle 2

(d) By now you should have one region remaining that can have a location where the net field is 0 N/C. Determine the coordinate of this location.

In: Physics

Cost and purchase price are the two different measurements companies use to evaluate the purchasing performance....

  1. Cost and purchase price are the two different measurements companies use to evaluate the purchasing performance. What is the benefit of developing performance measures that focus on cost versus purchase price? If the cost is a better performance measurement than cost, should purchase price be used as a performance measure at all? Why or why not?

  1. What is your understanding of the difference between effectiveness and efficiency measures? Are these two measurements independent from each other? When should a firm focus on purchasing effectiveness measures? When should a firm focus on purchasing efficiency measures?

In: Operations Management

add the following numbers using 16-bit 2's complement. show all the steps and calculations. Please also...

add the following numbers using 16-bit 2's complement.
show all the steps and calculations.
Please also show steps to verify that the answer is correct.

2368 and -772

In: Computer Science