A variety of plants are used as folk medicine in the treatment of hypertension.
Laboratory analyses show that a purified extract from one of these plants decreases
production of aldosterone in an animal model.
Complete the sentences below to explain how this anti-hypertensive plant extract might
work. In each case indicate the enzyme, hormone or receptor targeted and explain how the
action of the extract on this target would result in reduced aldosterone production.
A. The purified extract inhibits…
(60-word limit)
B. The purified extract blocks…
(60-word limit)

A 37-year-old man is diagnosed with Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML).

a. What is the molecular mechanism that makes this kind of cancer?(1/2 page)

b. What is the first-line treatment for CML and what is the rationale for this pharmacotherapy?(1/4 page)

c. What are the mechanisms of resistance to imatinib pharmacotherapy of CML?(1/4 page)

d. What other cancers and diseases are effectively treated with imatinib?(1/4 page)

e. What are the common and important side effects of therapy with imatinib(1/4 page)

Briefly describe the linear flow of electrons from water to NADPH during the light reaction of photosynthesis.

You are studying a group of Oregonian beavers, and you are interested in the population genetics of a single locus. You genotype 100 beavers and discover that for your locus of interest, there are 55 A¹A¹ homozygotes, 20 A¹A² heterozygotes, and 25 A²A² You estimate that the frequency of the A¹ allele is ["0.65", "0.35", "0.20"]         and that the expected number of A¹A² heterozygotes under Hardy-Weinberg equilibrium should be [ "12.25", "45.5", "50"]

choose number value for both blanks

In details, provide and discuss two experimental examples of GMO from (i) plants, (ii) animals and (iii) bacteria, illustrating the tools that researchers have used to overcome these challenges.

How important (quantitatively) is variation in genes affecting the Tor pathway to human longevity?

Please support answer with citations of studies

How important (quantitatively) is telomere length at birth to human longevity?

46. The filtration coefficient can be decreased by

a. increased MAP

b. decreased TPR

c. decreased venous pressure

d. none of the above

44. Extracellular edema results from

a. increased capillary hydrostatic pressure

b. decreased capillary hydrostatic pressure

c. increased osmotic pressure in the capillary

d. decreased osmotic pressure in the interstitial compartment

43. Hypoosmotic overhydration can be caused by

a. SIADH

b. DI

c. DM

d. none of the above

44. Extracellular edema results from

a. increased capillary hydrostatic pressure

b. decreased capillary hydrostatic pressure

c. increased osmotic pressure in the capillary

d. decreased osmotic pressure in the interstitial compartment

43. Hypoosmotic overhydration can be caused by

a. SIADH

b. DI

c. DM

d. none of the above

42. Addison's disease is associated with

a. decreased sodium levels

b. hyperkalemia

c. both a and b

d. none of the above

41. Cushing syndome leads to

a. hyponatremia

b. hypernatremia

c. hyerkalemia

d. none of the above

Several haploid strains of Saccharomyces cerevisiae grow well on YPD but do not grow on minimal media unless adenine is added to the minimal media. Some of those strains accumulate a red pigment and, thus, produce red or pink colonies. How would you determine the biochemical pathway that is defective in these yeast strains? How would you assign the functions to the genes that are mutated in these strains?

How is the body affected by Asthma? Explain in detail the cells, organs, organ systems affected by Asthma.

What are some of the best cognitive tests for regular people and why?

what's the relation between teratomas and ES cells, and the experiments to show their similarity

Compare the phenotypic variation seen in Mendelian inheritance, incomplete dominance, codominance, epistasis, and polygenic inheritance.

Suppose you return to the population after 10 generations and observe 80 black, 240 brown and 180 tan individuals. Explain how you would use the H-W model to determine if there has been statistically significant evolutionary change (change in genetic composition) in the population. Include the following terms in your answer: null hypothesis, observed and expected genotype frequencies, chi-square. Recall that you would need to do the chi-square calculation using observed and expected numbers of individuals of each genotype, not using observed and expected frequencies.