Questions
Why is the incidence rate of melanoma on the rise and why do some melanoma drugs,...

Why is the incidence rate of melanoma on the rise and why do some melanoma drugs, like Nexavar, work poorly, but drugs like Keytruda and Tafinlar work significantly better?

In: Biology

Explain the general mechanism for the simultaneous transport of Na+ and K+ by the Na+/K+ ATPase...

Explain the general mechanism for the simultaneous transport of Na+ and K+ by the Na+/K+ ATPase (aka. Na+/K+ pump) describing:
The result of this transport on the concentrations of Na+ and K+ inside and outside of the cell
How the binding of Na+ and K+ are related to the conformation changes on the protein
We discussed F-type pumps, which can also function in the reverse direction (i.e. ATP synthase). Explain how this protein can function both as a pump and as a "channel-like protein" (although the mechanism of proton transport is not the same as a typical channel) depending on the direction in which protons move (down or against their free energy gradient). How is ATP hydrolysis or synthesis associated to the movement of protons in each case?
Explain why the cystic fibrosis conductance regulator (CFTR) does not function as a pump even though it is a member of the ABC transporter family (what type of protein does CFTR behave like?)

In: Biology

Describe the role that mobile DNA elements may have played in evolution. PLEASE cite source(s) and...

Describe the role that mobile DNA elements may have played in evolution.

PLEASE cite source(s) and NO wikipedia. thank you!

In: Biology

Describe the three kinds of stimuli that are responsible for the opening and closing of gated...

Describe the three kinds of stimuli that are responsible for the opening and closing of gated ion channels in animal cells
Discuss the general characteristics of porins and explain how these are similar to/or different from ion channels
Discuss the transport of water molecules via aquaporins, taking into consideration the effect of having an increased number of aquaporin proteins on a cell that would not typically express high levels of this protein.
Explain the difference between facilitative uniporters, symporters, and antiporters

In: Biology

A patient with recurrent Neisseria infections is evaluated for complement deficiency. C3, C4, and C5 levels...

A patient with recurrent Neisseria infections is evaluated for complement deficiency. C3, C4, and C5 levels are all within normal limits. CH50 values are below the reference range. What could explain these results?

A. Patient has a deficiency of C1

B. Patient has non-functioning C4

C. Patient has non-functioning C5

D. Patient has a deficiency of Factor D

In: Biology

Analyze what is meant by "the transport of an ion across a membrane is determined by...

Analyze what is meant by "the transport of an ion across a membrane is determined by its electrochemical potential." In doing this, describe the factors that must be taken into account when considering whether the transport of a charged solute across a membrane is endergonic or exergonic. Consider how this compares to uncharged solutes.
Compare simple diffusion and osmosis
Given that most cells are hypertonic relative to their environment, describe how this in turn affects the movement of water into cells and the adaptations of animal and plant cells.
Discuss the reasons for the differences in transport rate observed for facilitated carriers compared to channels. Consider how the mechanism via which these proteins allow the movement of solutes will in turn affect the rate at which the solutes are transported.

In: Biology

why in lab do you usually fill the dissecting tray with about 2-4 cm of water?

why in lab do you usually fill the dissecting tray with about 2-4 cm of water?

In: Biology

"A key assumption is that crossing over is random. In which case, would you have an...

"A key assumption is that crossing over is random. In which case, would you have an equal number of recombinants?"

Does this mean that each of the totals for the recombinant groups should all be relatively similar to each other if crossing over is actually random?

In: Biology

Which statement below best describes the difference between quantitative and discrete traits: (a) discrete traits result...

Which statement below best describes the difference between quantitative and discrete traits:

(a) discrete traits result from the action of many genes, while quantitative traits involve a single genetic locus

(b) discrete traits cannot be categorized into a few distinct phenotypes

(c) quantitative traits result from the action of many genes, while discrete traits involve a single genetic locus

(d) quantitative traits can be easily categorized into a few distinct phenotypes

In: Biology

Define, compare, and contrast direct and indirect competition. Provide an example of how each of these...

Define, compare, and contrast direct and indirect competition. Provide an example of how each of these general phenomena shapes the distribution of organisms in shallow marine habitats

In: Biology

Discuss the location, general characteristics, and relative abundance of glycolipids and glycoproteins in cellular membranes Describe...

Discuss the location, general characteristics, and relative abundance of glycolipids and glycoproteins in cellular membranes
Describe the general functions of the glycolipids and glycoproteins
Compare the mobility of membrane proteins to that of membrane lipids and explain the factors that influence the mobility of membrane proteins

In: Biology

Discuss the location, general characteristics, and relative abundance of glycolipids and glycoproteins in cellular membranes Describe...

Discuss the location, general characteristics, and relative abundance of glycolipids and glycoproteins in cellular membranes
Describe the general functions of the glycolipids and glycoproteins
Compare the mobility of membrane proteins to that of membrane lipids and explain the factors that influence the mobility of membrane proteins

In: Biology

Discuss the general structure and function of lipid rafts Compare the 3 types of membrane proteins...

Discuss the general structure and function of lipid rafts
Compare the 3 types of membrane proteins in terms of their affinity for the hydrophobic interior of the membrane and the functions they typically have in cells. Think about how some of these functions are dependent on the presence of other types of membrane proteins (e.g. given that some peripheral membrane proteins anchor integral membrane proteins, how would removing peripheral proteins affect the mobility of integral membrane proteins?)
Discuss the meaning of membrane asymmetry
Explain why integral membrane proteins are considered amphipathic.

In: Biology

1. Discuss another important function of the electrochemical proton gradient that is indirectly related to ATP...

1. Discuss another important function of the electrochemical proton gradient that is indirectly related to ATP production.
2. Explain what an uncoupling agent is and describe how uncoupling agents dissipate the proton motive force
3. Discuss the reasons why naturally-occurring uncoupling proteins, which are especially abundant in brown adipose tissue of mammals, can be used as a source of heat production during exposure to cold temperatures.

In: Biology

Pick one class of CFTR mutations and brainstorm 2 examples of specific mutations that could fall...

Pick one class of CFTR mutations and brainstorm 2 examples of specific mutations that could fall in the class you have chosen. Many versions of correct answers are possible for each class mutations. Use your understanding of how the cell works and propose 2 mutations. Explain how they will work. For example, class I mutations is associated with no CFTR protein being made. Think how could that happen.

In: Biology