Question

Describe how influenza A and HIV differ in genome composition and what this difference means for their replication and generation of new virions.

can u tell me please in briefly

Answer 1

Influenza A virus genome is consist of eight negative sense single stranded RNA segments which remain in separate viral ribonucleoprotein (vRNP) complexes. This remain in a single virus particle. When they enter into host cells, vRNPs enters into the nucleus and there their RNA are replicated by RNA dependent RNA Polymerase enzyme. Viral proteins are also synthesized . Then vRNPs are exported out of the nucleus where they are assembled into mature viral particle which are released from the host cell by budding.

HIV genome is consist of two identical single stranded RNA molecules. They remain enclosed with the virus particle. They entry into the host cell by binding with specific receptor molecules. After integration into host cell, their RNA is being transcribed into DNA by the enzyme reverse transcriptase which convert RNA to DNA. After formation of DNA, it become integrated into host chromosome. Then the viral DNA become a part of host DNA and replicates with it. It codes for proteins and also RNA. new viral particles are assembled using these RNAs and proteins and they are released by budding from the host cell.