what are the immunological markers and molecular genetics related to ACUTE LEUKOCYTE LEUKEMIA AND ACUTE MELOID...

what are the immunological markers and molecular genetics related to ACUTE LEUKOCYTE LEUKEMIA AND ACUTE MELOID Leukemia?

Expert Solution

ACUTE LEUKOCYTE LEUKEMIA

Immunological markers

# Glycoprotein (gp100/CD10). It is a B cell antigen.

# T-cell antigen (gp40, CD7) and cytoplasmatic or surface CD3.

Molecular genetical abnormalities

# Chromosomal translocation of t(9;22)(q34;q11), and this chromosomal translocation corresponding to BCR-ABL1 gene mutation.

# Chromosomal translocation of t(4;11)(q21;q23), and this chromosomal translocation corresponding to MLL-AFA4, abn11q23/MLL gene mutation.

# Chromosomal translocation of t(1;19) (q23;p13) and this chromosomal translocation corresponding to PBX-E2A gene mutation.

ACUTE MELOID LEUKEMIA

Immunological markers

# Myeloid specific antigens CD13 and CD117

Molecular genetical abnormalities

# Chromosomal translocation of t(8;21)(q22;q22) and this chromosomal translocation corresponding to RUNX1-RUNX1T1 gene mutation.

# Chromosomal inversion of (16)(p13.1q22) or Chromosomal translocation of t(16;16)(p13.1;q22) and this chromosomal inversion & translocation corresponding CBFB-MYH11 gene mutation.

gladiator answered 2 years ago

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