Question

In: Biology

What are the genetic mutations that lead to ALL (Acute Lymphoblastic Leukemia) for T-cells and the...

What are the genetic mutations that lead to ALL (Acute Lymphoblastic Leukemia) for T-cells and the ALL for B-cells?

Solutions

Expert Solution

Acute lymphoblastic leukemia (ALL) is mainly a disease of childhood that arises from recurrent genetic alterations that block precursor B- and T-cell differentiation and drive aberrant cell proliferation and survival

T cell ALL

It mainly associated with the deregulated expression of normal transcription factor proteins.

It is a result of chromosomal rearrangements juxtaposing promoter and enhancer elements of T-cell receptor genes TRA@ (14q11), TRB@ (T-cell receptor b, 7q34-35), TRG@ (T-cell receptor g, 7p15) and TRD@ (T-cell receptor d, 14q11) to important transcription factor genes.

The rearrangements are reciprocal translocations, and lead to a deregulation of transcription of the partner gene by juxtaposition with the regulatory region of one of the TCR loci .

Bcell ALL

It occurs due to the mutations such as

t(9;22) (q34;q11.2) BCR-ABL1,

t(v;11q23) MLL rearranged,

t(12;21)(p13;q22) TEL-AML1 (ETV6-RUNX1),

t(5;14)(q31;q32) IL3-IGH,

t(1;19) (q23;p13.3) E2A-PBX1 (TCF3-PBX1)


Related Solutions

what is acute lymphoblastic leukemia (ALL),and what is the prognosis?
what is acute lymphoblastic leukemia (ALL),and what is the prognosis?
Acute promyelocytic leukemia (acute myeloid leukemia) with t(15;17)(q22;q12); P M L-R A R A Acute myeloid...
Acute promyelocytic leukemia (acute myeloid leukemia) with t(15;17)(q22;q12); P M L-R A R A Acute myeloid leukemia with t(9;11)(p22;q23); MLLT 3-MLL CBC and Differential findings: Bone Marrow Aspirate/Biopsy findings: Cytochemistry: Immunophenotyping Cytogenetics/Molecular genetics Misc Relevant Information Acute myeloid leukemia with t(6;9)(p23;q34); DEK-NUP214 CBC and Differential findings: Bone Marrow Aspirate/Biopsy findings: Cytochemistry: Immunophenotyping Cytogenetics/Molecular genetics Misc Relevant Information Acute myeloid leukemia (megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1 CBC and Differential findings: Bone Marrow Aspirate/Biopsy findings: Cytochemistry: Immunophenotyping Cytogenetics/Molecular genetics Misc Relevant Information Acute...
What are the differences between acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL)? For each...
What are the differences between acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL)? For each type of leukemia, explain how it originates and the key signs and symptoms.
1. Make a table to differentiate the 4 common types of leukemia: Acute lymphocytic leukemia (ALL),...
1. Make a table to differentiate the 4 common types of leukemia: Acute lymphocytic leukemia (ALL), Chronic lymphocytic leukemia (CLL), Acute myeloid leukemia (AML), and Chronic myeloid leukemia (CML) according to incidence, physiologic alterations, clinical manifestations, management, and prognosis. 2. Formulate a Nursing Care Plan for a patient with Acute Leukemia. 3. Enumerate the nursing implications for the administration of blood components.
Make a table to differentiate the 4 common types of leukemia: Acute lymphocytic leukemia (ALL), Chronic...
Make a table to differentiate the 4 common types of leukemia: Acute lymphocytic leukemia (ALL), Chronic lymphocytic leukemia (CLL), Acute myeloid leukemia (AML), and Chronic myeloid leukemia (CML) according to incidence, physiologic alterations, clinical manifestations, management, and prognosis. • Formulate a Nursing Care Plan for a patient with Acute Leukemia. • Enumerate the nursing implications for the administration of blood components
Make a table to differentiate the 4 common types of leukemia: Acute lymphocytic leukemia (ALL), Chronic...
Make a table to differentiate the 4 common types of leukemia: Acute lymphocytic leukemia (ALL), Chronic lymphocytic leukemia (CLL), Acute myeloid leukemia (AML), and Chronic myeloid leukemia (CML) according to incidence, physiologic alterations, clinical manifestations, management, and prognosis. Formulate a Nursing Care Plan for a patient with Acute Leukemia. Enumerate the nursing implications for the administration of blood components.
82) What is the name of the genetic mechanism that allows B cells or T cells...
82) What is the name of the genetic mechanism that allows B cells or T cells to produce specific antibodies? Homeostasis Gene rearrangement Excretion Antigen presentation 83) Which below describes the Humoral Immune Response A) involves activation and clonal selection of Cytotoxic T cells B) involves activation and clonal selection of B cells, resulting in production of secreted antibodies C) Lymphocytes are screened for host reactivity in the Thymus gland 84) Which below describes the Cell Mediated Immune Response A)...
what are the immunological markers and molecular genetics related to ACUTE LEUKOCYTE LEUKEMIA AND ACUTE MELOID...
what are the immunological markers and molecular genetics related to ACUTE LEUKOCYTE LEUKEMIA AND ACUTE MELOID Leukemia?
Explain how natural selection, genetic drift, mutations, and/or gene flow all lead to human genetic variation, using the examples from lab discussion.
Explain how natural selection, genetic drift, mutations, and/or gene flow all lead to human genetic variation, using the examples from lab discussion.
In the FAB classification of leukemia, Acute Myelomonocytic Leukemia is:   a. M1 b. M2 c. M3...
In the FAB classification of leukemia, Acute Myelomonocytic Leukemia is:   a. M1 b. M2 c. M3 d. M4 e. M5 Which FAB classification is represented by the following data: Blasts comprise 50% of the nucleated cells in the peripheral blood 30% of blasts are Peroxidase weakly positive Most Blasts are non-specific esterase positive All Blasts are specific esterase negative       a. M2 b. M3 c. M5 d. M6 e. M7
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT