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In the FAB classification of leukemia, Acute Myelomonocytic Leukemia is:   a. M1 b. M2 c. M3...

In the FAB classification of leukemia, Acute Myelomonocytic Leukemia is:  

a. M1

b. M2

c. M3

d. M4

e. M5

Which FAB classification is represented by the following data:

Blasts comprise 50% of the nucleated cells in the peripheral blood

30% of blasts are Peroxidase weakly positive

Most Blasts are non-specific esterase positive

All Blasts are specific esterase negative      

a. M2

b. M3

c. M5

d. M6

e. M7

Solutions

Expert Solution

The FAB (French-American-British) classification of leukemia, Acute Myelomonocytic Leukemia is:  

a. M1- Acute myeloblastic leukemia with minimal maturation,

b. M2- Acute myeloblastic leukemia with maturation,

c. M3- Acute promyelocytic lukemia,

d. M4- Acute myelomonocytic leukemia with eosinophilia,

e. M5- Acute monocytic leukemia.

Q. Blasts comprise 50% of the nucleated cells in the peripheral blood

30% of blasts are Peroxidase weakly positive

Most Blasts are non-specific esterase positive

All Blasts are specific esterase negative    

a. M2- 30% of blasts are Peroxidase weakly positive

b. M3: Acute promyelocytic leukemia (APL)- Most Blasts are non-specific esterase positive,

c. M5: Acute monocytic leukemia- Blasts comprise 50% of the nucleated cells in the peripheral blood,

d. M6: Acute erythroid leukemia- 50% erythroid precursors of nucleated cells in BM, 20% myeloblasts of non-erythroid cells in BM,

e. M7: Acute megakaryoblastic leukemia- 50% of the blasts are megakaryocytic lineage.


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