Question

1.) Compare and contrast population genetics with Mendelian genetics of individuals and molecular genetics.

2.) What are the two Hardy-Weinberg conclusions and why are they both needed?

3.) What use is the Hardy-Weinberg equilibrium principle?

4.) What are the 5 crucial assumptions of the Hardy-Weinberg equilibrium principle?

5.) Describe the ADH study and explain its relevance.

6.) Why won’t CCR5- Δ32 allele increase in frequency?

Answer 1

Answer 1 population genetics is a Integration of evolution by natural selection with Mendelian genetics where as molecular population genetics explains genetic variation and molecular evolution from population genetics principles.

2 The hardy Weinberg first conclusion - if an infinitely large random mating population is free from outside evolutionary forces (i.e mutation migration and natural selection ), then the gene

Frequencies will not change over time and frequencies in the next generation will be p2 for the AA genotype, 2pq for Aa genotype and q2 for aa genotype. And these two are needed because it provides a way to estimate allele frequencies for a trait in which heterozygotes are indistinguishable from one of the homozygotes.

3 Use of hardy Weinberg equilibrium - it provides framework to observe how and why population deviate from ideal allele frequencies by mathematically proving that allele frequencies Do Not Change.

5 crucial assumptions are as follows - no selection, no mutation , no migration, no change events, random mating, ideal population.

6 CCR5 ∆32 plays important role in resistant of HIv won't increase because of the heterozygous carriers have reduced susceptibility to infection and delayed onset of AIDS and frequency varies with geographically areas.