Question

outline an interaction which occurs between adipocytes and lymphocytes and the outcome of this interaction. and whether this interaction occurs during embryonic development or adult stage of development.

Answer 1

An interaction occuring between adipocytes and lymphocytes is called T cell proliferation or we can say that it results in proliferation of t cells .

Here what happens is thar adipocytes change all their structural and functional properties into some de-differentiated cells there will be a structural change .And the Isolated mature adipocytes expressed significantly higher levels of CIITA, major histocompatibility complex II (human leukocyte antigen [HLA]-DR) and costimulatory signal molecule CD80 compared with adipocytes after the de-differentiation process.

Also human leukocyte antigen-G, that prevents the immune responses of mesenchymal stromal cells, was expressed at lower level in mature adipocytes compared with that of the de-differentiated adipocytes. In line with these molecular data, functional results showed the result of immunoregulatory properties between adipocytes before and after de-differentiation process.

And the mature adipocytes stimulated the proliferation of total lymphocytes and immunoselected cell populations CD3+, CD4+ and CD8+ in a direct contact-dependent way that involved the major histocompatibility complex I and II pathways.

Moreover, adipocytes also secreted potential chemo-attractant factors, but result of the reaction showed that adipocyte-derived culture medium was not sufficient enough to activate lymphocyte proliferation, suggesting that a direct contact between adipocytes and immune cells was needed. However, specific mature adipocyte cytokines enhanced lymphocyte proliferation in a mixed lymphocyte reaction.This is a small outline of the reaction.

The outcome is In cross-talk occurs between adipocytes and lymphocytes within adipose tissue involving T-cell chemo-attraction by mature adipocytes.

This development happens in the adult stage.