Question

outline a direct or indirect interaction between adipocytes and myocytes and what is the outcome of this interaction? and if this occurs in embryonic or adult stage of development?

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Answer 1

In direct or indierct interaction of adipocytes and myocytes for example leads to obesity. Obesity leads to adipose tissue inflammation that is characterized by increased release of proinflammatory molecules and the recruitment of activated immune cells. Although macrophages are present in the highest number among the immune cells in obese adipose tissue. With weight gain in obesity a chronic low garde inflammation develops associated with several metabolic diseases such as type 2 diabetes mellitus, atherosclerosis and liver steatosis.This low grade inflammatory response is mainly mediated by adipocytes regulating the release of adipocytokines such as IL-6,TNF- and MCP-1 that stimulates the infiltration of macrophages into adipose tissue and their activation. Although there is a direct contact between adipocytes and macrophages owing to the crown like structure formation not much is known about the consequences of these interactions.