Where are protein components of the extracellular matrix synthesized? A.at the rough ER B.in the extracellular...

Where are protein components of the extracellular matrix synthesized?

A.at the rough ER

B.in the extracellular layer itself

C.in the plasma membrane

D.in the Golgi apparatus

Expert Solution

Ans. Option A. at the rough ER

Just like any other secreted proteins, The protein components of Extracellular matrix are synthesized in the rough Endoplasmic Reticulum.

But the synthesis of protei compnents of Extracellular matrix is much more complex as number of steps are involved between translation and functional protein transport through Golgi appartus and post-translational modifications.

The multistep process of ECM protein components can be summarized as:

Transcription in Nucleus

Translation or protein synthesis in rough ER in Cytoplasm

Assembly of monomeric subunits (Endoplasmic Reticulum)

Processing modifications (ER/ Golgi apparatus)

Secretion (Exocytotic vesicles)

Assembly to fibrils (Extracellular space)

Functional ECM protein components

gladiator answered 2 years ago

Starting in the rough Endoplasmic Reticulum (rough ER), describe the path of a new protein through...

Starting in the rough Endoplasmic Reticulum (rough ER), describe the path of a new protein through the endomembrane system and out of the cell through the plasma membrane. What is the role of each organelle (be sure to include the role of the Golgi, nucleus, and smooth ER) as the new molecule is synthesized? How are other macromolecules manufactured in the cell and how are they transported differently in the endomembrane system? Why are vesicles so important in the endomembrane...

Explain the overall FUNCTION of the extracellular matrix protein families (as a whole), such as the...

Explain the overall FUNCTION of the extracellular matrix protein families (as a whole), such as the collagens, fibronectins, laminins, and integrins. Please explain it as a short answer

Describe how components of the cytoskeleton, cytoplasm, cell surface and extracellular matrix interact to form cell...

Describe how components of the cytoskeleton, cytoplasm, cell surface and extracellular matrix interact to form cell junctions and the roles of distinct junction types in skin

A detailed explanation of the role of the Extracellular Matrix?

compare protein transport to ER with protein transport from ER to Golgi. what is the diffrence...

compare protein transport to ER with protein transport from ER to Golgi. what is the diffrence between the two methods?

1. if you think of the extracellular matrix (ECM) as a fiber-reinforced matrix, which of the...

1. if you think of the extracellular matrix (ECM) as a fiber-reinforced matrix, which of the following are the fiber forming elements? (choose as many as apply) a. elastin b. glycoproteins c. proteoglycans d. collagen 2.if you had to perform an experiment where you had to evaluate cytotoxicity, which of the following assays would be options to consider. (choose as many as apply) a. western blot b. PCR c. MTS assay d. RT-PCR e. MTT assay f. northern blot g....

Describe six different molecules that compose the extracellular matrix.

Proteins that are moved into the endoplasmic reticulum (ER) are Group of answer choices fully synthesized...

Proteins that are moved into the endoplasmic reticulum (ER) are Group of answer choices fully synthesized in the cytoplasm and then moved into the ER. fully folded when they are transported into the ER. further modified within the ER. will eventually move to the nucleus.

Steroid hormones are derived from _ and synthesized by _. Amino acids, rough endoplasmic reticulum Amino...

Steroid hormones are derived from ___ and synthesized by ___. Amino acids, rough endoplasmic reticulum Amino acids, smooth endoplasmic reticulum Cholesterol, ribosomes Cholesterol, smooth endoplasmic reticulum Proteines, mitochondria The hormones that regulate blood calcium levels are ____ Insulin and glucagon Thyroxine and triiodothyronine Antiduretic hormone and glucocorticoids Epinephrine and norepinephrine Parathyroid hormone and calcitonin Which of the following hormones is responsible for the “fight or flight” response? Thyroxine Parathyroid hormone Epinephrine Glucagon mineralocorticoids Glucagon and insulin are secreted by the____...

A newly synthesized protein generally folds up into a __________________ conformation.

A newly synthesized protein generally folds up into a __________________ conformation. All the information required to determine a protein’s conformation is contained in its amino acid __________________. On being heated, a protein molecule will become __________________ as a result of breakage of __________________ bonds. On removal of urea, an unfolded protein can become __________________. The final folded conformation adopted by a protein is that of __________________ energy.Words: denatured composition noncovalent irreversible stable reversible highest covalent renatured lowest unstable sequence

Question