Where are protein components of the extracellular matrix synthesized? A.at the rough ER B.in the extracellular...

Where are protein components of the extracellular matrix synthesized?

A.at the rough ER

B.in the extracellular layer itself

C.in the plasma membrane

D.in the Golgi apparatus

Solutions

Expert Solution

Ans. Option A. at the rough ER

Just like any other secreted proteins, The protein components of Extracellular matrix are synthesized in the rough Endoplasmic Reticulum.

But the synthesis of protei compnents of Extracellular matrix is much more complex as number of steps are involved between translation and functional protein transport through Golgi appartus and post-translational modifications.

The multistep process of ECM protein components can be summarized as:

Transcription in Nucleus

Translation or protein synthesis in rough ER in Cytoplasm

Assembly of monomeric subunits (Endoplasmic Reticulum)

Processing modifications (ER/ Golgi apparatus)

Secretion (Exocytotic vesicles)

Assembly to fibrils (Extracellular space)

Functional ECM protein components

gladiator answered 1 year ago

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