compare protein transport to ER with protein transport from ER to Golgi. what is the diffrence...

compare protein transport to ER with protein transport from ER to Golgi. what is the diffrence between the two methods?

Expert Solution

* Synthesis of proteins entering the endoplasmic reticulum is initiated on free ribosomes.

* Synthesis of all proteins begins in the cytosol compartment.

* For proteins entering the secretory or Lysosomal pathways, the first step is targeting to the endoplasmic reticulum.

* This targeting relies on a targeting signal encoded in the N terminal portion of the protein.

* The targeting signal is recognized by a specific receptor that results in the protein entering the endoplasmic reticulum.

* Proteins that are completely translocated into the endoplasmic reticuluum. These proteins are soluble (not membrane proteins) and are destined for secretion, or for transfer to lysosomes. In all of these cases the proteins are never part of membranes.

* Translation of all proteins begins on free ribosomes.

From ER to Golgi

* Correctly folded and assembled proteins in the ER are packaged into COPII-coated transport vesicles that pinch off from the ER membrane.

* Thereafter the coat is shed and the vesicles fuse with one another to form vesicular tubular clusters, which move on microtubule tracks to the Golgi apparatus.

* Many resident ER proteins slowly escape, but they are returned to the ER from the vesicular tubular clusters and the Golgi apparatus by retrograde transport in COPI-coated vesicles.

gladiator answered 1 year ago

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