A mutation positioned in a nonsplicing region causes the spliceosome to recognize this mutation as being...

A mutation positioned in a nonsplicing region causes the spliceosome to recognize this mutation as being part of a consensus sequence, thereby splicing in that location. This occurred because the mutation:

a. eliminated the splicing consensus sequence, causing the spliceosome to splice elsewhere

b. changed the snRNA sequence, causing it to hybridize to an altered sequence on the transcript

c. altered the consensus sequence in the promoter & changed the rate of transcription initiation

d. created an ideal or close to ideal sequence that attracted the spliceosome

e. changed the way the spliceosome protein positioned the snRNA responsible for splicing

Expert Solution

Answer:option B

The individual information in each site of the sequences having functional binding sites are related to the the thermodynamic entropy and free energy of binding.The information content of a nucleic acid binding is related to the affinity of it's interaction with proteins and other macromolecular complexes during mRna splicing.

Altering a nucleotide with high information (implying high prevalence and conservation at that position) will have a greater impact on binding than if a less well conserved base were altered.

So by altering or changing SnRna sequence having nucleotide with high information and causing it to hybridize to an altered sequence on the transcript.As a result of mutation change in information occurs and it can be expressed in terms of ∆Ri is the difference between Ri,final and Right, initial values.(where Ri final is the information of the sequence containing the variant and Ri initial is the information of the reference (wild type) sequence.

gladiator answered 2 years ago

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