Question

In: Biology

what would be the most likely effect of a mutation in region 1 of the trp...

what would be the most likely effect of a mutation in region 1 of the trp operon leader sequence changing to two trp codons into gly codons. please explain thoroughly i am confused

Solutions

Expert Solution

Answer:

  • The expression of Trp operon is regulated by transcriptional atteunation.
  • Trp operon contains a leader sequence between the operator and the structural genes.
  • When the tryptophan is low, the structural genes including leader sequence gets transcribed but when tryptophan level is high, structural genes are not transcribed but the short sequence of 140 ntds is transcribed.
  • The leader sequence contains four regions - Region 1, has 2 trp codons, Region 2, and Region 3 and 4 that has poly (U).
  • When tryptophan is high in the medium, Region 1&2 and Region 3&4 base pairs to form hair pin structure, transcription stops.
  • But during its low level, region 2 and 3 base pairs, inhibiting the base pairing between region 3&4 and transcription continues.
  • So if two Trp codons changed to Gly, then the ribosome will continue the translation of leader sequence and will stop at region 2 (contains stop codon) resulting in the Region 3&4 base pairing, turning OFF the transcription.

Please Rate My Answer.........Thank..........u...

gladiator answered 1 year ago
Next > < Previous

Related Solutions

In the E. coli trp operon, what would be the effect of a deletion in the...
In the E. coli trp operon, what would be the effect of a deletion in the region 2 sequence, which would prevent it from forming stable RNA hairpin structure with either regions 1 or 3? A) The Trp repressor could not bind to the operator and trp transcription will be high, even in the presence of high tryptophan concentration. B) Translation of the leader sequence could not be initiated. C) No effect on trp operon transcription. D) Transcription of the...
A. Which type of mutation do you feel would be most likely to be influenced by...
A. Which type of mutation do you feel would be most likely to be influenced by natural selection, those that result in changes of the third codon position, or those that result in changes of the first codon position? Explain your reasoning. B. In many animals inbreeding among close relatives reduces the ability of their offspring to survive. Explain why this occurs. Please correct answer. Thanks
A. Which type of mutation do you feel would be most likely to be influenced by...
A. Which type of mutation do you feel would be most likely to be influenced by natural selection, those that result in changes of the third codon position, or those that result in changes of the first codon position? Explain your reasoning. B. In many animals inbreeding among close relatives reduces the ability of their offspring to survive. Explain why this occurs.
A. Which type of mutation do you feel would be most likely to be influenced by...
A. Which type of mutation do you feel would be most likely to be influenced by natural selection, those that result in changes of the third codon position, or those that result in changes of the first codon position? Explain your reasoning.     B. In many animals inbreeding among close relatives reduces the ability of their offspring to survive. Explain why this occurs.
What is the likely effect of each of the following mutations of the trpL region on...
What is the likely effect of each of the following mutations of the trpL region on attenuation control of trp operon gene transcription? Explain your reasoning. a. Region 3 is deleted. b. Region 4 is deleted. c. The entire trpL region is deleted. d. The start (AUG) codon of the trpL polypeptide is deleted. e. Two nucleotides are inserted into the trpL region immediately after the polypeptide stop codon. f. Twenty nucleotides are inserted into the trpL region immediately after...
A cis-acting mutation that leads to MINIMAL expression of the lac operon would most likely be...
A cis-acting mutation that leads to MINIMAL expression of the lac operon would most likely be in the CAP binding site. Is this true or false, and why? Thanks!
Describe the likely effect on gene expression of a mutation in the lac operon: a) that...
Describe the likely effect on gene expression of a mutation in the lac operon: a) that delegate the operator b) that mutates the lacI gene inactivating the repressor c) that the promoter mutates in the -10 region
there is a mutation in a gene impairing fatty acid synthesis. what enzyme is most likely...
there is a mutation in a gene impairing fatty acid synthesis. what enzyme is most likely being affected? how will a defect in fatty acid synthesis affect embryonic development, if at all?!
Describe the effect of government's cutting spending would most likely have on: (1) the aggregate demand...
Describe the effect of government's cutting spending would most likely have on: (1) the aggregate demand curve (2) inflation (3) unemployment rate
a) Which DNA mutation is more likely to have a detrimental effect on the protein it...
a) Which DNA mutation is more likely to have a detrimental effect on the protein it codes for: a 2 base pair deletion from the middle of the coding sequence of a gene, or a 12-base pair deletion from the same region of the gene? Explain why? b) Would the outcome be different if the deletions happened within the gene’s intron? Explain why?
ADVERTISEMENT
Subjects
ADVERTISEMENT
Latest Questions
ADVERTISEMENT