Question

A couple have experienced multiple miscarriages, and a balanced translocation is suspected to be the cause. Which form of genetic testing would be most appropriate?

a. Microarray

b. Karyotype

c. Amniocentesis

d. Next-gen sequencing

Continuing from the last question, who should be tested first? a. The man b. The woman c. Neither partner takes priority

Answer 1

SOLUTION- option B that is KARYOTYPE is right

when assessing a new patient with two or more spontaneous losses, it is important to obtain POC karyotype results from past losses, if available or to obtain the tissues form those losses for subsequent genetic analysis. this allows the practitioner to determine more precisely whether a diagnostic workup for is indicated prior aneuploid losses likely reflect the high baseline rate of aneuploidy noted in all spontaneous miscarriages.if the fetal karyotype of one or more of the reported losses is unknown. assuming euploidy may result in an unnecessary set of diagnostic tests in a patient who may not have experienced reported unexplained losses and would be unlikely to benefit from further diagnostic testing. a karyotype is a picture of a person's chromosome the packages of genetic material that exists within the nucleus of every cell in the body.in order to obtain a parental karyotype, blood that is usually white blood cells from one or both parents is used. doctors used the test only for couples with an increased risk of having a chromosome related conditions

so both should be tested but men's first

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