In animal tissue, the rate of conversion of pyruvate of acetyl-CoA is regulated by the ratio...

In animal tissue, the rate of conversion of pyruvate of acetyl-CoA is regulated by the ratio of active, phosphorylated pyruvate dehydrogenase to inactive, unphosphorylated pyruvate dehydrogenase (PDG) complex. Explain the impact of the following regulators on the activity of pyruvate dehydrogenase complex in animal tissue extracts when treated with:

- high concentrations of acetyl-CoA

Solutions

Expert Solution

Answer . Effect of high concentrations of Acetyl Co A on PDH complex-

Pyruvate dehydrogenase complex is a multienzyme system, that contains 3 enzymes to fullfil one goal ( conversion of pyruvate into acetyl CoA).

These three enzymes are

E1- pyruvate dehydrogenase

E2- dihydrolipoyl trans acetylase

E3- dihydrolipoyl dehydrogenase.

Pyruvate dehydrogenase is active when it is a dephosphoenzyme and it is inactive when it is a phosphoenzyme . The attachment of phosphate group is done by PDH kinase enzyme. When Acetyl coA is in excess it activated the PDH kinase enzyme to form inactive phosphoenzyme a, and inhibits the activity of PDH complex.

For diagrammatic presentation kindly refer image.

gladiator answered 1 year ago

Next > < Previous

Related Solutions

Pyruvate dehydrogenase complex catalyzes the conversion of pyruvate to acetyl CoA. In this reaction, five cofactors...

Pyruvate dehydrogenase complex catalyzes the conversion of pyruvate to acetyl CoA. In this reaction, five cofactors (a) thiamine pyrophosphate; (b) nicotine adenine dinucleotide (NAD+); (c) acetylCoA; (d) flavin adenine dinucleotide (FAD); and (e) lipoamide participate at various steps of the reaction. Explain the role of each cofactor in this reaction. You must use the chemical structures and electronic properties of the intermediates to justify your answers.

The conversion of pyruvate into acetyl CoA uses what enzyme? Pyruvate Hydrolase Pyruvate Carboxylase Lactate Dehydrogenase...

The conversion of pyruvate into acetyl CoA uses what enzyme? Pyruvate Hydrolase Pyruvate Carboxylase Lactate Dehydrogenase Citrate Synthase None of the above Jenny’s lungs have an intrapulmonic pressure of 762 mmHg and an intrapleural pressure of 757 mmHg. Atmospheric pressure is 759 mmHg. What is happening to Jenny? Jenny is inhaling Jenny’s ventilation is at a rest Jenny is exhaling Jenny is suffocating None of the above Which of the following enzymes does ubiquinone transport electrons to in the ETC?

In glycolysis, the conversion from pyruvate to acetyl CoA is irreversible, but I found that during...

In glycolysis, the conversion from pyruvate to acetyl CoA is irreversible, but I found that during the synthesis of FA, acetyl CoA can be synthesized to citrate -> OAA -> Malate ->pyruvate when Citric acid shuttle, why we cannot say that pyruvate can turn back to acetyl CoA?

Briefly explain the steps by which the pyruvate dehydrogenase complex converts pyruvate to acetyl CoA and...

Briefly explain the steps by which the pyruvate dehydrogenase complex converts pyruvate to acetyl CoA and deposits it in the mitochondrial matrix. What cofactors are used, what are the products formed? How is the complex activity regulated?

The pyruvate dehydrogenase complex catalyzes the reaction pyruvate → acetyl-CoA (Reaction 0 in the TCA cycle)....

The pyruvate dehydrogenase complex catalyzes the reaction pyruvate → acetyl-CoA (Reaction 0 in the TCA cycle). It is activated by AMP, CoA and NAD+, but it is inhibited by ATP, acetyl-CoA and NADH. What is the biochemical logic of this regulatory mechanism of the citric acid cycle? (In your response, be sure to address why specific molecules are activators and why specific molecules are inhibitors)

In the absence of oxygen, pyruvate cannot be converted into acetyl-CoA. It is instead converted to ____...

In the absence of oxygen, pyruvate cannot be converted into acetyl-CoA. It is instead converted to ____ and must go to the Cori Cycle into glucose to generate energy. You would notice this during your exercise. lactic acid ketones glucose lactose

What is the term for conversion of acetyl CoA into energy in the form of ATP...

What is the term for conversion of acetyl CoA into energy in the form of ATP in the presence of oxygen? a. oxidative phosphorylation b. citric acid cycle c. proton gradient d. cellular respiration e. electron-transport chain

11. In the Pyruvate Dehydrogenase complex, the acetyl unit is passed to the coA directly from...

11. In the Pyruvate Dehydrogenase complex, the acetyl unit is passed to the coA directly from __________________. A. biotin B. TPP C. FAD D. pyruvate E. lipoyllysine 13. A common feature of molecules that signal through steroid and metabolite hormone receptors is: A. they are hydrophobic B. they are polar C. their receptors are mostly found in the cell surface membrane D. their receptors signal through second messengers. E. their...

State if each of the following processes produce or consume ATP: a. pyruvate forms acetyl CoA...

State if each of the following processes produce or consume ATP: a. pyruvate forms acetyl CoA b. First six reactions of glycolysis

In muscle tissue, the ratio of phosphorylase a to phosphorylase b determines the rate of conversion...

In muscle tissue, the ratio of phosphorylase a to phosphorylase b determines the rate of conversion of glycogen to glucose 1‑phosphate. Classify how each event affects the rate of glycogen breakdown in isolated muscle tissue. Increased rate Decreased rate No change Answer Bank AMP allosteric binding activates phosphorylase b removal of phosphate groups from phosphorylase a addition of phosphorylase b kinase [ATP] exceeds [AMP] addition of a kinase inhibitor treatment with insulin addition of a phosphatase inhibitor treatment with glucagon

Subjects