The pyruvate dehydrogenase complex catalyzes the reaction pyruvate → acetyl-CoA (Reaction 0 in the TCA cycle)....

The pyruvate dehydrogenase complex catalyzes the reaction pyruvate → acetyl-CoA (Reaction 0 in the TCA cycle). It is activated by AMP, CoA and NAD+, but it is inhibited by ATP, acetyl-CoA and NADH. What is the biochemical logic of this regulatory mechanism of the citric acid cycle? (In your response, be sure to address why specific molecules are activators and why specific molecules are inhibitors)

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gladiator answered 2 years ago

Pyruvate dehydrogenase complex catalyzes the conversion of pyruvate to acetyl CoA. In this reaction, five cofactors...

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