In glycolysis, the conversion from pyruvate to acetyl CoA is irreversible, but I found that during...

In glycolysis, the conversion from pyruvate to acetyl CoA is irreversible, but I found that during the synthesis of FA, acetyl CoA can be synthesized to citrate -> OAA -> Malate ->pyruvate when Citric acid shuttle, why we cannot say that pyruvate can turn back to acetyl CoA?

Expert Solution

gladiator answered 2 years ago

Pyruvate dehydrogenase complex catalyzes the conversion of pyruvate to acetyl CoA. In this reaction, five cofactors...

Pyruvate dehydrogenase complex catalyzes the conversion of pyruvate to acetyl CoA. In this reaction, five cofactors (a) thiamine pyrophosphate; (b) nicotine adenine dinucleotide (NAD+); (c) acetylCoA; (d) flavin adenine dinucleotide (FAD); and (e) lipoamide participate at various steps of the reaction. Explain the role of each cofactor in this reaction. You must use the chemical structures and electronic properties of the intermediates to justify your answers.

The conversion of pyruvate into acetyl CoA uses what enzyme? Pyruvate Hydrolase Pyruvate Carboxylase Lactate Dehydrogenase...

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In animal tissue, the rate of conversion of pyruvate of acetyl-CoA is regulated by the ratio...

In animal tissue, the rate of conversion of pyruvate of acetyl-CoA is regulated by the ratio of active, phosphorylated pyruvate dehydrogenase to inactive, unphosphorylated pyruvate dehydrogenase (PDG) complex. Explain the impact of the following regulators on the activity of pyruvate dehydrogenase complex in animal tissue extracts when treated with: - high concentrations of acetyl-CoA

11. In the Pyruvate Dehydrogenase complex, the acetyl unit is passed to the coA directly from...

11. In the Pyruvate Dehydrogenase complex, the acetyl unit is passed to the coA directly from __________________. A. biotin B. TPP C. FAD D. pyruvate E. lipoyllysine 13. A common feature of molecules that signal through steroid and metabolite hormone receptors is: A. they are hydrophobic B. they are polar C. their receptors are mostly found in the cell surface membrane D. their receptors signal through second messengers. E. their...

Briefly explain the steps by which the pyruvate dehydrogenase complex converts pyruvate to acetyl CoA and...

Briefly explain the steps by which the pyruvate dehydrogenase complex converts pyruvate to acetyl CoA and deposits it in the mitochondrial matrix. What cofactors are used, what are the products formed? How is the complex activity regulated?

The pyruvate dehydrogenase complex catalyzes the reaction pyruvate → acetyl-CoA (Reaction 0 in the TCA cycle)....

The pyruvate dehydrogenase complex catalyzes the reaction pyruvate → acetyl-CoA (Reaction 0 in the TCA cycle). It is activated by AMP, CoA and NAD+, but it is inhibited by ATP, acetyl-CoA and NADH. What is the biochemical logic of this regulatory mechanism of the citric acid cycle? (In your response, be sure to address why specific molecules are activators and why specific molecules are inhibitors)

In the absence of oxygen, pyruvate cannot be converted into acetyl-CoA. It is instead converted to ____...

In the absence of oxygen, pyruvate cannot be converted into acetyl-CoA. It is instead converted to ____ and must go to the Cori Cycle into glucose to generate energy. You would notice this during your exercise. lactic acid ketones glucose lactose

What is the term for conversion of acetyl CoA into energy in the form of ATP...

What is the term for conversion of acetyl CoA into energy in the form of ATP in the presence of oxygen? a. oxidative phosphorylation b. citric acid cycle c. proton gradient d. cellular respiration e. electron-transport chain

Carbohydrates aid fat metabolism by: A. Donating acetyl-CoA during beta-oxidation B. Generating pyruvate needed to form...

Carbohydrates aid fat metabolism by: A. Donating acetyl-CoA during beta-oxidation B. Generating pyruvate needed to form oxaloacetate which keeps the citric acid cycle turning as fats form acetyl-CoA C. Preventing the formation of ketones by generating acetyl-CoA D.Generating glucose which provides energy needed for beta-oxid ation which forms acetyl-CoA for the citric acid cycle

State if each of the following processes produce or consume ATP: a. pyruvate forms acetyl CoA...

State if each of the following processes produce or consume ATP: a. pyruvate forms acetyl CoA b. First six reactions of glycolysis

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