In the absence of oxygen, pyruvate cannot be converted into acetyl-CoA. It is instead converted to ____...

In the absence of oxygen, pyruvate cannot be converted into acetyl-CoA. It is instead converted to ____ and must go to the Cori Cycle into glucose to generate energy. You would notice this during your exercise.

lactic acid

ketones

glucose

lactose

Expert Solution

Answer: Lactic acid

Explanation: During normal metabolism glucose entering glycolysis gets converted into pyruvate and ATP. Then after in presence of oxygen, pyruvate gets converted into acetyl CoA.

- But when oxygen is absent (in muscles during exercise) pyruvate gets fermented into lactic acid. The enzyme involved is the lactate dehydrogenase.

- This lactic acid enters Cori cycle where and gets converted into pyruvate which in turn gets converted to glucose via the process called gluconeogenesis.

- So, when normal aerobic condition is met after then this lactic acid can be converted into chemical energy (ATP).

Incorrect options:

- Ketones: Ketone bodies are formed from acetyl CoA and not from pyruvate.

- Glucose: Pyruvate gets first converted into lactic acid in the muscle. Then when it enters Cori Cycle it gets converted into pyruvate which in turn gets converted into glucose.

- Lactose: Lactose is the molecule formed from glucose and galactose. So there is no such formation during the process mentioned above.

gladiator answered 1 year ago

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