In: Biology
Antimicrobials and their action.
Antimicrobial agent |
Infectious agent |
General target and outcome |
Side effects to host |
Sulfonamides |
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Nystatin and Amphoteracyn B |
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Chloramphenicol |
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Vancomycin Bendazoles |
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Tetracycline |
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Penicillins and Cephalosporins |
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Griseofulvin |
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Flouroquinolines |
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Quinines |
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Streptomycin |
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Acyclovir |
Antimicrobial agent | Infectious agent | General target and outcome | Side effects to host |
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Sulfonamides | often used in combinations with agents like trimethoprim(for trachoma) and pyrimethamine(for malaria) |
mode of action is inhibition of other metabolic processes. sulfomides interfere with folic acid synthesis by preventing addition of PABA(para-aminobenzoic acid)into folic acid molecule. mainly used for the treatment of acute urinary tract infections. |
hypersensitivity reactions like rashes,erythema nodosum, and photosensitivity, nausea, vomiting,etc |
Nystatin and Amphoteracyn B | A tetraene agent is used topically. |
Liposomal encapsulation was found to target infected tissues as the capillary size at the infected areas is larger, so the drug is to be released at that specific area. Itis ued intrathecally for brain fungal infections. |
main side effect to host is nephrotoxicity, reduced by formulation change |
Chloramphenicol | Streptomyces venezuelae and effective against gram+ and gram- bacteria and anaerobes | It inhibits protein synthesis and prevents protein chain elongation by inhibiting the petridyl transferase acitivity of bacterial ribosome. | Blood Dyscrasias(bone marrow depression), Gastrointestinal reactions, Neurotoxic reactions, hypersensitivity reactions. |
Vancomycin Bendazoles |
methicillin- resistant Staphylococcus aureus |
its primary target is murein monomers and inhibits the late-stages of cell wall synthesis in dividing bacteria |
serious allergic reactions, low blood pressure, wheezing, indigestion, hives, itching, dizziness |
Tetracycline | Gram positive bacteria and with organisms by energy dependent active transport | its target is by binding reversibly to he 30S subunit of the bacterial ribosome, which inhibits addition of amino acids to the growing peptide resulting in inhibition of protein synthesis. | Gastrointestinal reactions like nausea, vomiting, diarrhea,etc and liver toxicity, Kidney toxicity, Photosensitization, vestibular reactions etc |
Penicillins and Cephalosporins | Leptospira interrogans serovar bataviae |
used for treatment of human leptospirosis. The general target is Pencillin binding proteins and then it disrupts the synthesis of the peptidoglycan layer forming the bacterial cell wall. |
Stomach discomfort, nausea, diarrhea, blood abnormalities, rach or itching |
Griseofulvin | fungistatic agent- and Griseofulvin is a metabolic product of penicillin griseofulvin with potent activity against fungal agents | used to treat superficial fungal skin infections like tinea capitis and pedis. It interferes with cell division, and inhibit fungal DNA replication and has been used for superficial dermatophyte infections. | It can cause transient mild to moderate serum aminotransferase elevations and has very rarely been linked to clinically apparent acute drug induced liver injury |
Flouroquinolines | P.aeruginosa |
used to treat for a variety of illnesses such as respiratory and urinary tract infections. It inhibits bacterial replication by blocking their DNA replication pathway |
nausea, diarrhea, headache, dizziness, lightheadeness or trouble sleeping |
Quinines | Plasmodium falciparum | used to treat malaria and babesiosis and can be taken by mouth or used intravenously and quinine is the ingredient in tonic water that gives it a bitter taste. | fever, chills, weakness, sweating, vomiting, stomach pain, diarrhea, chest pain, trouble breathing, dizziness |
Streptomycin | gentamicin, amicasin, neomycin | it binds to 30S subunit to inhibit formation of initiation complex. | nephrotoxicity, octotoxicity, neuromuscular blokade |
Acyclovir | virus |
used to treat herpes virus infections, chickenpox, and shingles HSV(herpes simplex virus) DNA Polymerase is the antiviral target of PMEA |
it can cause AKI from intratubular crystal deposition when administered intravenously, particularly at high doses, and nausea,diarrhea, headache, or vomiting may occur. |