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Medications affecting coagulation Coumadin Heparin Lovenox Mode of Action Indications Dosage/Route Side Effects Labs to Monitor...
Medications affecting coagulation
Coumadin Heparin Lovenox
Mode of Action
Indications
Dosage/Route
Side Effects
Labs to Monitor
Antidote
Patient teaching
Solutions
Expert Solution
- Coumadin
It is an anticoagulant.
It acts by decreasing the production of clotting protein in the blood.There by the blood formed are thinned in size.
It is Indicated in Deep vein thrombosis, pulmonary embolism,Arterial embolism,heart valve replacement
The dose for Adults are 2-5 mg once a day and then a maintenance dose of 2-10 mg is done.
It is administered orally
The usual side effects are nausea, anorexia, abdominal pain,rash, itching, swelling, dizziness, trouble breathing
Lab values like INR,PT,PT INR,PTT had to be monitored
The antidote for this is Vitamin K
Patient has to report if any of the above side effects are greater
- Heparin
It is also an anticoagulant
It inactivates thrombin and activated factor 10
It is indicated for DVR, pulmonary embolism, thromboembolism, unstable angina,in kidney dialysis machine
It is administered via IV or Subcutaneous
The usual dose is 5000 units (TDS) and depending upon the need
Side effects are bleeding,pain at site, decreased platelet, alopecia, osteoporosis, increased serum aminotransferase and potassium
The lab value to be monitored are serum potassium and serum aminotransferase
The antidote is Protamine Sulphate
Teach patient about side effects and to get help when symptoms are severe
- Lovenox
It is also an anticoagulant
It acts by binding to antithrombin then it inactivates clotting factor10 &8
It is indicated for surgery, prolonged bed ridden patients no mobilisation,angina ,heart attack
The route of administration is subcutaneous and intravenous
Dosage
for abdominal surgery 40mg _OD for 7 to 10 days
Surgery of hip and knee 40 mg _OD for 3 weeks
Acute illness 40 mg _ OD for 6 to 12 days
DVT 1 mg/kg/12 hours
Side effects are mild irritation,pain at site, bruises, redness, thrombocytopenia,echymosis, nausea,anaemia, dyspnea, hematuria
The antidote is Protamine
Monitor lab value of platelet, aminotransferase , clotting factors
Inform the patient about side effects and report to physician if any problems
Nightingale answered 2 years agoRelated Solutions
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