Question

In: Nursing

aluminum hydroxide (Amphojel)- Phosphate binders provide the following: Generic Name Brand Name Classification (pharmacological/physiological action on...

aluminum hydroxide (Amphojel)- Phosphate binders

provide the following:

  1. Generic Name
  2. Brand Name
  3. Classification (pharmacological/physiological action on the body)
  4. Dosage
  5. Route, Adverse Effects/side effect/life-threatening effects and
  6. Nursing Considerations (teaching, assessments, labs)

please cite the reference thanks

Solutions

Expert Solution

Aluminium hydroxide (Amphojel)

Generic Name: Aluminium hydroxide

Brand Name : Amphojel, Dialume, Alu- cap, Alugel, Alu- Tab

Classifications:

Pharmacological classification:

Antacid- Acid Neutralizers

Pharmacological action: Amphojel suspension reacts chemically to neutralize or buffer existing quantities of stomach acids but have no direct effects on its production. The action increases gastric pH, providing symptomatic relief of hyperacidity. Small amount of aluminium from aluminium hydroxide is absorbed from the intestine.

It is also gastrointestinal agent & Adsorbent

Dosage:

General dosage information for the active ingredient contained in Amphojel :

Aluminium hydroxide (oral suspension,oral capsule,oral tablet, compound powder)

  • In Adult Dosage from & strengths

Oral suspension :320mg/5mL

Antacid : 5-30 mL PO between meals and HS or as directed

Peptic Ulcer Disease: 5-30mL between meals and HS or as directed

Hyperphosphatemia: 300-600 mg PO 3 times/day between meal and HS

  • In Case Pediatric Dosages

Oral suspension 320mg/ 5mL

Hyperphosphatemia 50-150 mg/kg/day PO divided q4- 6hr; titrate dose to keep phosphorus within normal range.

Adverse effects

GI: Constipation,fecal Impaction, intestinal obstruction.

CNS: Dialysis Dementia ( thought to be due to aluminium intoxication)

Metabolic: Hypophosphatemia,hypomagnesemia

Some other side effects: signs of an allergic reaction, like rash, hives. Constipation

Nursing consideration:( Teaching, Assessment,Labs)

  • Note number and consistency of stools. Constipation is common and dose related. Intestinal obstruction from fecal concretions has been reported.
  • Lab : Monitor periodic serum calcium and phosphorus levels with prolonged high dose therapy or impaired renal function.
  • Patient and Family education
  • Increase phosphorus in diet when taking large doses of these antacid for prolonged period; hyphosphatemia cam develop within 2 wk of continuous use of these antacids. The older adult in the poor nutritional state is at high risk.
  • Seek medical help if indigestion is accompanied by shortness of breath, sweating or chest pain, if stools are dark or tarry ,or if symptoms are recurrent when taking this medication.

Reference: 1. Margolis DJ, Lewis VL. A literature assessment of use of miscellaneous topical agents, growth factors and skin equivalents for the treatment of pressure ulcers. Dermatol surg.1995 Feb ; 21 (2): 145-8

2. Chan A,Ignoffo RJ. Survey of topical oral solutions for the treatment of chemo- induced oral mucositis. J oncol pharma pract.2005 Dec;11(4): 139- 43 .


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