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aluminum hydroxide (Amphojel)- Phosphate binders
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Aluminium hydroxide (Amphojel)
Generic Name: Aluminium hydroxide
Brand Name : Amphojel, Dialume, Alu- cap, Alugel, Alu- Tab
Classifications:
Pharmacological classification:
Antacid- Acid Neutralizers
Pharmacological action: Amphojel suspension reacts chemically to neutralize or buffer existing quantities of stomach acids but have no direct effects on its production. The action increases gastric pH, providing symptomatic relief of hyperacidity. Small amount of aluminium from aluminium hydroxide is absorbed from the intestine.
It is also gastrointestinal agent & Adsorbent
Dosage:
General dosage information for the active ingredient contained in Amphojel :
Aluminium hydroxide (oral suspension,oral capsule,oral tablet, compound powder)
Oral suspension :320mg/5mL
Antacid : 5-30 mL PO between meals and HS or as directed
Peptic Ulcer Disease: 5-30mL between meals and HS or as directed
Hyperphosphatemia: 300-600 mg PO 3 times/day between meal and HS
Oral suspension 320mg/ 5mL
Hyperphosphatemia 50-150 mg/kg/day PO divided q4- 6hr; titrate dose to keep phosphorus within normal range.
Adverse effects
GI: Constipation,fecal Impaction, intestinal obstruction.
CNS: Dialysis Dementia ( thought to be due to aluminium intoxication)
Metabolic: Hypophosphatemia,hypomagnesemia
Some other side effects: signs of an allergic reaction, like rash, hives. Constipation
Nursing consideration:( Teaching, Assessment,Labs)
Reference: 1. Margolis DJ, Lewis VL. A literature assessment of use of miscellaneous topical agents, growth factors and skin equivalents for the treatment of pressure ulcers. Dermatol surg.1995 Feb ; 21 (2): 145-8
2. Chan A,Ignoffo RJ. Survey of topical oral solutions for the treatment of chemo- induced oral mucositis. J oncol pharma pract.2005 Dec;11(4): 139- 43 .