Questions
Part I – The Tour You are an intern working in the Atlanta, GA office of...

Part I – The Tour
You are an intern working in the Atlanta, GA office of Dr. Priya Wayne, MD. Dr. Wayne is a specialist in rare neuromuscular and musculoskeletal disorders. You’ve been working with Dr. Wayne for the last year and due to this experience you’ve gained a great deal of knowledge about the human body and muscle physiology. You’re also a college student and working with Dr. Wayne has allowed you to gain first-hand experience with some of the material that you’re learning in your human physiology course. Just last week you had to turn in an assignment comparing and contrasting disorders of the neuromuscular junction. You learned all about several issues, including myasthenia gravis, sarin, curare, botulism, and Eaton-Lambert syndrome.
Today a group of high school students is coming for a tour and Dr. Wayne has asked you to prepare some information about muscles to present to the students. Specifically, Dr. Wayne has asked you to discuss the neuromuscular junction (NMJ), skeletal muscle contraction, and explain some of the issues that can occur when signaling between neurons and muscles does not go as planned.
Questions
Use the word bank to match the appropriate letter to the definitions/descriptions on the next page.
(a) Sodium
(b) Nicotinic acetylcholine receptor (nACh) (c) Myosin
(d) Actin
(e) Acetylcholine (ACh)
(f) Depolarization
(g) Motor end plate
(h) Acetylcholinesterase (AChE)
(i) Synaptic vesicles
(j) T-tubule
(k) Sarcoplasmic reticulum (l) Dihydropyridine receptor (m) Ryanodine receptor
(n) Synaptic terminal
(o) Sarcolemma
(p) Sarcomere
*These four undergraduate students contributed equally to the creation of this case study and are listed in alphabetical order.
Case copyright held by the National Center for Case Study Teaching in Science, University at Buffalo, State University of New York. Originally published September 29, 2016. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work. Photograph by Victoria Garcia, Open Stax, <https://cnx.org/contents/[email protected]:mU03zyTM@2/Interactions-of-Skeletal-Muscl>, cc by 4.0.
NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE 1. ___ Thin contractile protein involved in cross-bridge formation, comes in filamentous or globular forms.
2. ___ Store neurotransmitters, and following a Ca2+ driven signal, dump neurotransmitters into the synapse.
3. ___ The structure at the end of the axon that contains neurotransmitters and vesicles.
4. ___ The functional unit of the muscle fiber that includes the A-band, I-band, H-zone and the M-line.
5. ___ The ion responsible for depolarizing the muscle membrane by traveling through the nACh receptor, down its electrochemical gradient.
6. ___ Located on the sarcoplasmic reticulum and once opened, allows Ca2+ flow from the sarcoplasmic reticulum into the sarcoplasm.
7. ___ Thick filamentous contractile protein involved in cross-bridge formation, has a club-like appearance with a “head.”
8. ___ A neurotransmitter derived from choline; responsible for sending the excitatory signal in the neuromuscular junction.
9. ___ These invaginations allow depolarization of the muscle membrane to quickly penetrate from the sarcolemma to the myofibril.
10. ___ Large and complex terminal formation by which an axon of a motor neuron establishes synaptic contact with a skeletal muscle fiber, transmitting neural impulses to a muscle.
11. ___ The plasma membrane of a muscle fiber.
12. ___ The enzyme responsible for stopping the ACh signal. Functions by metabolizing ACh into choline, which is recycled, and acetate.
13. ___ Responsible for opening a ligand-gated Na+/K+ channel in the muscle membrane when the proper ligand binds to it.
14. ___ A L-type calcium channel in the muscle cell membrane, activated upon depolarization, couple depolarization signal to release of calcium.
15. ___ An electrical change which brings the relative charge of the inside of the cell more positive; necessary for transmission of electrical impulses within a cell, or from one cell to another.
16. ___ Modified endoplasmic reticulum, stores and releases calcium.


Explain the organization/classifications of the Human Nervous System.
1. Which component(s) will be your main focus in this case study

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In small groups, you will defend the use of your protein., ***PLANT PROTEIN*** You will describe...

In small groups, you will defend the use of your protein., ***PLANT PROTEIN*** You will describe in detail:

1. the composition

2. mechanism of action

3. rate of absorption and synthesis

4. timing of consumption

5. recommended dose

6. pros and cons

In addition, you should address the following:

1. What types of athletes would best benefit from your protein?

2. Are there any side effects of excessive consumption?

3. Estimate the cost of using the supplement for 1 week, 1 month, and 1 year.

Be creative with how you defend your supplement. Provide examples for even samples.

Please I need answer for #4 ASAP!!!

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A patient has had a cholecystectomy (gallbladder removal) because of gallstones and chronic inflammation of the...

A patient has had a cholecystectomy (gallbladder removal) because of gallstones and chronic inflammation of the gallbladder. He will be released from the hospital tomorrow. As a clinician, what recommendations would you offer to help him adapt to life without a gallbladder?

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1...Which of the following types of hair is generally not found on bald men? lanugo hairs...

1...Which of the following types of hair is generally not found on bald men?

lanugo hairs
All are found on bald men.
terminal hairs
vellus hairs

a...What structural characteristic of the epidermis prevents water loss and the entry of pathogens?

stratified squamous epithelium
tactile disc
dermal papillae
melanocyte

b...If you have a manicure and get your cuticles pushed back, the manicurist is technically doing what?

Pushing a portion of the stratum corneum back from the eponychium
Pushing a portion of the stratum spinosum back from the lunula.
Pushing a portion of the stratum germanitivum back from the hyponichium
Pushing a portion of the stratum lucidum back from the nail body.

c....Which layer of the dermis contains the capillaries, lymphatic vessels, and sensory nerve fibers that supply the epidermis?

subcutaneous layer
stratum basale
reticular layer
papillary layer

d....Reduction in the number of elastic fibers in the skin of the elderly results in __________.

osteoporosis
hair loss
wrinkles
skin dryness

e....All of the following are functions of the subcutaneous layer EXCEPT __________.

stabilizing the position of the skin relative to underlying tissues
thermoregulation
acting as a blood reservoir
detection of fine touch

The layer that contains areolar connective tissue is the __________ layer.

epidermal
subcutaneous
reticular
keratin

Which of the following is NOT an aging effect on skin?

Hair follicles become more active, producing longer, darker hairs.
Glandular activity decreases.
Blood supply to the dermis is reduced.
The epidermis thins and the integument becomes less resilient.

Why are the elderly more prone to skin infections?

They have a thinner epidermis.
They have fewer dendritic (Langerhans) cells.
Tissue repairs take longer.
All of the listed responses are corre

Individuals who live in locations with limited exposure to sunlight can have abnormal bone development due to an inability to absorb calcium and phosphate ions from the small intestine. Why does a limited exposure to sunlight cause abnormal bone development?

Cholecalciferol, or vitamin D3, is necessary for the normal absorption of calcium and phosphate ions. Vitamin D3 is made by cells in the epidermis due to exposure to sunlight. Without enough exposure to sunlight, the body won't produce enough vitamin D3.
People exercise less in areas where there is limited sunlight. This lack of exercise can cause abnormal development of bones.
People sleep more in areas of limited sunlight.
People are more depressed in areas with limited sunlight, and depression can cause abnormal development of bones.

The skin can move easily over the underlying muscles because of the loose connective tissue within the __________.

dermis
cutaneous membrane
epidermis
hypodermis

Two women are comparable in age, body conformation, and are pregnant at the same time, but one experiences stretch marks, while the other does not. What would be a possible hypothesis for why there was an observed difference?

The woman with stretch marks has a greater collagen-to-elastic fiber ratio.
The woman may have different gender babies.
The woman with less stretch marks has larger skin cells.
The woman without stretch marks has more cholesterol in her diet, which affects her cell membranes.

Collagen to repair a deep skin wound is produced by __________.

keratinocytes
macrophages
epidermal fibroblasts
fibroblasts

Skin exposed to ultraviolet light increases production of __________.

keratin
carotene
collagen
melanin

If an injury covers a large area, dermal repairs first begin with the division and migration of what cell type?

epidermal cells
fibroblast cells
melanocytes
epithelial cells

The process of skin repair after injury begins with __________.

formation of scar tissue
inflammation
formation of granulation tissue
formation of a blood clot

The epidermal layer that consists almost entirely of keratin is the __________.

reticular layer
stratum granulosum
stratum basale
stratum corneum

Which of these is NOT an accessory structure of the skin?

sebaceous glands
hair
hair follicles
dermis

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write about the formed elements of the blood. Describe each structure and explain its function.

write about the formed elements of the blood. Describe each structure and explain its function.

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Please give interesting examples or unusual species of the fungus Chytridiomycota

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The orthopaedic surgeon needs to carry out surgery on a patient which involves the removal of...

The orthopaedic surgeon needs to carry out surgery on a patient which involves the
removal of a failed intervertebral disc. Compare a spinal cage with an intervertebral
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inserted in to the patient.

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How does the principle of homeostasis relate to endocrine function? Provide a specific example of how...

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1. True or false: Exocrine glands release useful, non-hormone secretions into the blood. 2. What is...

1. True or false: Exocrine glands release useful, non-hormone secretions into the blood.

2. What is the function of serous fluid?

3.

Which membrane is responsible for lubricating the hip and shoulder joints?

mucous membrane
serous membrane
cutaneous membrane

synovial membrane

4. True or false: The secretions of endocrine glands can alter cell function.

5. The __________ is a layer of protein that aids in attaching an epithelial tissue to the connective tissue deep to it?

6. The electrical signals that stimulate muscle contraction are created by ______ tissue?

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1. A patient with OTC deficiency has recurrent hyperammonemic events over a 3-month period despite reduced...

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What is an animal disease that involves the simple squamous epithelium?

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Explain the concept of net filtration pressure. Describe the two main forces that drive the direction...

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