Question

For high risk group screening (i.e. injection drug users) as compared to generla population screening, what is the best in terms of levels of sensitivity and specificity. Explain why.

Answer 1

There are some imperative contemplations concerning screening high-hazard ladies. To start with, in view of an absence of premalignant injuries, beginning period discovery is of urgent significance in the reconnaissance; in this manner, it is trusted that screening will accomplish a more extended in general survival of patients. Second, on account of the high ovarian malignancy chance, randomized controlled preliminaries in these ladies are dishonest. Yearly or semi-yearly screening with transvaginal ultrasound (TVU) and CA-125 assurance and a discretionary prophylactic medical procedure of the ovaries and fallopian tubes (reciprocal prophylactic salpingo-oophorectomy, or BPSO) is prescribed by a taskforce of the Cancer Genetics Studies Consortium (CGSC; Burke et al., 1997). These proposals were likewise connected in the Netherlands. In spite of these reasonable rules, there are restricted information with respect to the use of these rules. The effectiveness of yearly screening in low-and high-hazard patients by evaluating serum CA-125 and TVU observing isn't clear.

Affectability and specificity are terms used to assess a clinical test. They are autonomous of the number of inhabitants in intrigue exposed to the test.

Positive and negative prescient qualities are helpful while thinking about the estimation of a test to a clinician. They are subject to the commonness of the infection in the number of inhabitants in intrigue.

The affectability and specificity of a quantitative test are subject to the cut-off an incentive above or beneath which the test is sure. By and large, the higher the affectability, the lower the specificity, and the other way around.

The sensitivity of a clinical test refers to the ability of the test to correctly identify those patients with the disease.

The specificity of a clinical test refers to the ability of the test to correctly identify those patients without the disease.