Question

Could an unknown ancestry have any implications for diagnosis and the effectiveness of a Cystic Fibrosis treatment. Hint: identify the strengths and weaknesses of current research and problems or unresolved issues that warrant investigation in future studies

What kind of genetic tests are performed to diagnose CF?

Answer 1

Answer )

Cystic Fibrosis is a life threatening disease which affects the exocrine glands in the body which can have many consequnces in the organs connected to the glands for eg the salivary glands starts producing abnormally thick mucous saliva, pancreatic secretion gets blocked, respiratory and digestive difficuties.

It is inherited in the Autosomal Recessive manner, which means the disease only gets manifested in the individual who aquires a recessive trait of it from both of its parents.

One of the methods used in treating this illness is by gene therapy where gene correction is done in the patient even though it is thought to be not 100 % effective as many problems lay in the immune system concerning the bone marrow of the one diseased one, but still the known ancestral background does help in inculcating the gene therapy effectively than compared to someone who has no ancestral record of the same. The other treatment plans includes antibiotic treatments.

There are a few mothods of diagnosing the CysticFibrosis including :

Genetic tests
IRT also known as IMMUNOREACTIVE TRYPSINOGEN TEST

Sweat test

Chest X ray

Sputum test

Sialograohy for salivary gland dysfunction

The diagnosis can also be arrived by amalgamation of the few tests mentioned above.

I hope i was able to help you with the answer! :)