Among the alleles for the gene responsible for cystic fibrosis that have been identified, one mutant...

Among the alleles for the gene responsible for cystic fibrosis that have been identified, one mutant has been identified in which three amino acids in the middle of the protein sequence are changed. What change in the DNA sequence of the gene could cause such a mutation? (Choose the best answer):

Select one:

a. a single base pair deletion

b. insertion of three adjacent base pairs

c. a single base pair substitution

d. a single base pair insertion and a single base pair deletion a short distance 3' to the insertion

e. deletion of three adjacent base pairs

Expert Solution

The correct answer is -(d) [ EXPLANATION- when a single base pair has been inserted, it will produce a new amino acid(due to a shift of frame) and along with it a deletion few distances away from that mutation would cause to correct the shift in the frame, producing only 3 mutant amino acids, instead of the entire protein to get mutated]

Why not others-

a single base pair deletion--will change the sequence of the entire protein, because that would cause a frameshift mutation.

a single base pair substitution- will only produce a single mutant amino acid.

Insertion of 3 adjacent base pairs- This would produce a new amino acid along with the existing one(n+1). The amino acid will be a new one, not a mutant one.

deletion of 3 adjacent base pairs- This would omit a single amino acid from the protein sequence, without the production of any mutant amino acids.

gladiator answered 2 years ago

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