Question

The mother of a close friend of yours is diagnosed with moderate osteoporosis. She is prescribed two hormones, or supplements, or drugs that affect hormones or supplements.

1.) Tell me two possibilities for these medications, and describe how they would help her osteoporosis. Note: I don’t expect you to know any drug names, I’m asking you for what TYPES of drugs.

2.) The mother of your close friend is also told to exercise. Why? Although many types of exercise are appropriate, why is swimming generally not recommended?

Answer 1

Drugs useful for the treatment of osteoporosis .

1. Drugs which inhibit bone resorption

? Bisphosphonates

- These agents aare used in osteoporosis duee to its inhibitory effect on osteoclast mediated resorption

- These drugs accelerate the apoptosis of osteoclasts and also suppresses the differentiation of osteoclast precursors to mature osteoclasts.

- This results duee to the reduce in cholestrol synthesis as Bisphosphonates inhibits Farnesyl pyrophosphate synthatase .

?Selective Estrogen Receptor Modulators

?Estrogen inhibits bonee resorption directly and indirrectly by modulating the paracrine factors .

? It incrreases the antiresorptive and suppress the pro resorptive like Il 1&6 , TNF alpha .

? Estrogen helps in bone formation , defeciency of it results in osteoporosis in postmenopausal women.

?Calcium supplements such as calcitriol or vitamin D

It is used in the treatment or prophylaxis of osteoporosis

Calcitriol is the active form of vitamin D ,it increases the blood calcium level therfore it has to be used along with vitamin D . Synergestic activity of both will keep the bone healthy .

2. Exercises are adviced during osteoporosis but donot include high impact exercise which will make the bone more fragile . But doing exercises like briskwalking jogging yogas are recommended as it will strengthen ur bones .

In osteoporosis you arre adviced to do exercises which will imcrease the bone density , eo weight bearing exercises arre required .

In swimming there is no weight bearing .but it enhnace the cardiovascular activity .

? Maintaing a deit which includes calcium supplenents should be taken such as milk fish etc.