Fact:Without thiamine (vitamin B1), the body cannot convert pyruvate into acetyl-CoA, or use 6 of the...

Fact:Without thiamine (vitamin B1), the body cannot convert pyruvate into acetyl-CoA, or use 6 of the 22 amino acids in the Krebs cycle. Explain in detail why a person with a thiamine deficiency would have a reduced physical work capacity.

Detailed answer please!

Expert Solution

Without thiamine (vitamin B1), the body cannot convert pyruvate into acetyl-CoA, or use 6 of the 22 amino acids in the Krebs cycle. thiamine deficiency would have a reduced physical work capacity because don't get enough thiamine, you may first have nausea, vomiting, loss of appetite, fatigue and difficulty concentrating. ... If thiamine deficiency is severe, serious problems can result including loss of hearing, permanent nerve damage, coma, permanent brain damage, heart damage, liver damage, and death.

Thiamin (vitamin B1) helps the body's cells change carbohydrates into energy. The main role of carbohydrates is to provide energy for the body, especially the brain and nervous system. Thiamin also plays a role in muscle contraction and conduction of nerve signals. Thiamin is essential for the metabolism of pyruvate.

Energy is needed to work for that thiamin is essential so thiamine deficiency would have a reduced physical work capacity.

Sydney Mullin answered 1 year ago

In the absence of oxygen, pyruvate cannot be converted into acetyl-CoA. It is instead converted to ____...

In the absence of oxygen, pyruvate cannot be converted into acetyl-CoA. It is instead converted to ____ and must go to the Cori Cycle into glucose to generate energy. You would notice this during your exercise. lactic acid ketones glucose lactose

Briefly explain the steps by which the pyruvate dehydrogenase complex converts pyruvate to acetyl CoA and...

Briefly explain the steps by which the pyruvate dehydrogenase complex converts pyruvate to acetyl CoA and deposits it in the mitochondrial matrix. What cofactors are used, what are the products formed? How is the complex activity regulated?

Pyruvate dehydrogenase complex catalyzes the conversion of pyruvate to acetyl CoA. In this reaction, five cofactors...

Pyruvate dehydrogenase complex catalyzes the conversion of pyruvate to acetyl CoA. In this reaction, five cofactors (a) thiamine pyrophosphate; (b) nicotine adenine dinucleotide (NAD+); (c) acetylCoA; (d) flavin adenine dinucleotide (FAD); and (e) lipoamide participate at various steps of the reaction. Explain the role of each cofactor in this reaction. You must use the chemical structures and electronic properties of the intermediates to justify your answers.

The conversion of pyruvate into acetyl CoA uses what enzyme? Pyruvate Hydrolase Pyruvate Carboxylase Lactate Dehydrogenase...

The conversion of pyruvate into acetyl CoA uses what enzyme? Pyruvate Hydrolase Pyruvate Carboxylase Lactate Dehydrogenase Citrate Synthase None of the above Jenny’s lungs have an intrapulmonic pressure of 762 mmHg and an intrapleural pressure of 757 mmHg. Atmospheric pressure is 759 mmHg. What is happening to Jenny? Jenny is inhaling Jenny’s ventilation is at a rest Jenny is exhaling Jenny is suffocating None of the above Which of the following enzymes does ubiquinone transport electrons to in the ETC?

The pyruvate dehydrogenase complex catalyzes the reaction pyruvate → acetyl-CoA (Reaction 0 in the TCA cycle)....

The pyruvate dehydrogenase complex catalyzes the reaction pyruvate → acetyl-CoA (Reaction 0 in the TCA cycle). It is activated by AMP, CoA and NAD+, but it is inhibited by ATP, acetyl-CoA and NADH. What is the biochemical logic of this regulatory mechanism of the citric acid cycle? (In your response, be sure to address why specific molecules are activators and why specific molecules are inhibitors)

In animal tissue, the rate of conversion of pyruvate of acetyl-CoA is regulated by the ratio...

In animal tissue, the rate of conversion of pyruvate of acetyl-CoA is regulated by the ratio of active, phosphorylated pyruvate dehydrogenase to inactive, unphosphorylated pyruvate dehydrogenase (PDG) complex. Explain the impact of the following regulators on the activity of pyruvate dehydrogenase complex in animal tissue extracts when treated with: - high concentrations of acetyl-CoA

In glycolysis, the conversion from pyruvate to acetyl CoA is irreversible, but I found that during...

In glycolysis, the conversion from pyruvate to acetyl CoA is irreversible, but I found that during the synthesis of FA, acetyl CoA can be synthesized to citrate -> OAA -> Malate ->pyruvate when Citric acid shuttle, why we cannot say that pyruvate can turn back to acetyl CoA?

11. In the Pyruvate Dehydrogenase complex, the acetyl unit is passed to the coA directly from...

11. In the Pyruvate Dehydrogenase complex, the acetyl unit is passed to the coA directly from __________________. A. biotin B. TPP C. FAD D. pyruvate E. lipoyllysine 13. A common feature of molecules that signal through steroid and metabolite hormone receptors is: A. they are hydrophobic B. they are polar C. their receptors are mostly found in the cell surface membrane D. their receptors signal through second messengers. E. their...

The lack of vitamin B1 (thiamine) can lead to a disease called beriberi, which manifests as...

The lack of vitamin B1 (thiamine) can lead to a disease called beriberi, which manifests as cardiac and neurologic symptoms alongside elevated levels of pyruvate and α-ketoglutarate in the blood. Explain how a deficiency of this vitamin causes the increased levels of the two components.

State if each of the following processes produce or consume ATP: a. pyruvate forms acetyl CoA...

State if each of the following processes produce or consume ATP: a. pyruvate forms acetyl CoA b. First six reactions of glycolysis

Question