what is CCR5? What is the ligand for CCR5?

what is CCR5?

What is the ligand for CCR5?

Expert Solution

CCR5 is a C-C motif chemokine receptor type 5, similar to G coupled receptor proteins and mainly expressed on T-cells and macrophages. This is a receptor for C-C chemokines or beta chemokines which have two adjacent cysteine residues at their amino terminus.

This receptor is ligand for monocyte chemoattractant protein 2 (MCP2), macrophage inflammatory protein 1 alpha (MIP1 alpha), macrophage inflammatory protein 1 beta (MIP1 beta) and regulated on activated normal T expressed and secreted protein (RANTES). This receptor on binding to ligand transduces a signal by increasing intracellular calcium concentration and regulates granulocyte lineage proliferation and differentiation. This receptor acts as a coreceptor for HIV1 virus to enter cells.

gladiator answered 2 years ago

If a spherical ligand field is replaced by an octahedral ligand field, what changes in orbital...

If a spherical ligand field is replaced by an octahedral ligand field, what changes in orbital energies will accompany this?

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In all ligand titrations, the concentration of ligand is varied around the KD of the complex....

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What does binding of its ligand do to a receptor kinase?

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1. What is Y in terms of ligand binding? What is the definition of Kd? How...

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What are key ingredients required for docking?What is the difference between a ligand like benzene and...

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what is CCR5? What is the ligand for CCR5?

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Expert Solution

Related Solutions

If a spherical ligand field is replaced by an octahedral ligand field, what changes in orbital...

1a. What is CR3? What is the normal ligand for CR3, and what is the consequence...

In all ligand titrations, the concentration of ligand is varied around the KD of the complex....

What does binding of its ligand do to a receptor kinase?

1. What is Y in terms of ligand binding? What is the definition of Kd? How...

1. What is Y in terms of ligand binding? What is the definition of Kd? How...

Chloride and fluoride is a weak-field ligand. Cyanide is a strong-field ligand. Qualify each of these...

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