what is CCR5? What is the ligand for CCR5?

what is CCR5?

What is the ligand for CCR5?

Expert Solution

CCR5 is a C-C motif chemokine receptor type 5, similar to G coupled receptor proteins and mainly expressed on T-cells and macrophages. This is a receptor for C-C chemokines or beta chemokines which have two adjacent cysteine residues at their amino terminus.

This receptor is ligand for monocyte chemoattractant protein 2 (MCP2), macrophage inflammatory protein 1 alpha (MIP1 alpha), macrophage inflammatory protein 1 beta (MIP1 beta) and regulated on activated normal T expressed and secreted protein (RANTES). This receptor on binding to ligand transduces a signal by increasing intracellular calcium concentration and regulates granulocyte lineage proliferation and differentiation. This receptor acts as a coreceptor for HIV1 virus to enter cells.

gladiator answered 1 year ago

If a spherical ligand field is replaced by an octahedral ligand field, what changes in orbital...

If a spherical ligand field is replaced by an octahedral ligand field, what changes in orbital energies will accompany this?

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In all ligand titrations, the concentration of ligand is varied around the KD of the complex....

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What does binding of its ligand do to a receptor kinase?

1. What is Y in terms of ligand binding? What is the definition of Kd? How...

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1. What is Y in terms of ligand binding? What is the definition of Kd? How...

1. What is Y in terms of ligand binding? What is the definition of Kd? How are Y and Kd related? What is the meaning of affinity between a ligand and a protein? How is Kd related to affinity? 2. What do the binding curves of hemoglobin and myoglobin look like? Why are they different, what give hemoglobin’s curve a distinctive shape? How does a lower pH effect the hemoglobin binding curve?

Chloride and fluoride is a weak-field ligand. Cyanide is a strong-field ligand. Qualify each of these...

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HUMAN GROWTH HORMONE 1. Describe the ligand and any external receptors that bind to the ligand. If signaling can occur without an external ligand, explain how this can occur. 2. Describe how the signal is translocated from the exterior of the cell to the interior of the cell. Be sure to describe the specific activity of the receptor in initiating the intracellular signal. 3. Describe the propagation of the signal within the cell from the membrane receptor to the point...

What are key ingredients required for docking?What is the difference between a ligand like benzene and...

What are key ingredients required for docking?What is the difference between a ligand like benzene and a ligand like n-hexane? What can you do to account for this difference when docking the two ligands separately into the same binding pocket of the protein named T4 Lysozyme? For receptors that can undergo a large conformational change like G-protein coupled receptor (GPCR), what can you do in docking to account for this flexibility?

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what is CCR5? What is the ligand for CCR5?

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Expert Solution

Related Solutions

If a spherical ligand field is replaced by an octahedral ligand field, what changes in orbital...

1a. What is CR3? What is the normal ligand for CR3, and what is the consequence...

In all ligand titrations, the concentration of ligand is varied around the KD of the complex....

What does binding of its ligand do to a receptor kinase?

1. What is Y in terms of ligand binding? What is the definition of Kd? How...

1. What is Y in terms of ligand binding? What is the definition of Kd? How...

Chloride and fluoride is a weak-field ligand. Cyanide is a strong-field ligand. Qualify each of these...

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