Question

I have to write about noradrenaline  

- I should talk about its synthesis- (physiologic mechanisms and drugs or foods affecting them);

- storage in vesicles (physiology-like the name of the pump for storage and drugs, toxins or foods that interferes with it);

-its release-physiology and drugs or toxins that interfere;

-the termination of effect in the synapse (physiology-like enzymatic breakage or re-uptake

-about the drugs that affect the process

-and its receptors of these neurotransmitters and drugs acting on these receptors

- refer them as agonists and antagonists for relevant receptors).

I still have 3 more, I will post the questions individually

no need for figures if everything I asked for is explained.

Answer 1

1 )Synthesisof NorAdrenaline :

Tyrosine is transported into the sympathetic nerve axon. --> DOPA by tyrosine hydroxylase --> dopamine by DOPA decarboxylase --> Vesicular uptake of Dopamine -->Nor Adrenaline by dopamine beta hydroxylase

2) Dopamine is transported to the vesicle and converted into nor adrenaline by dopamine beta hydroxylase.

Vesicular uptake is blocked by - Reserpine

3). When calcium enters through voltage gated calcium channel the vesicle fuse with plama membrane and release nor adrenaline in synapse.

Nor adenaline Increases HR, and Blood pressure.

4.Its action is terminated by reuptake and metabolism. Reuptake into pre junctional neuron may be blocked by cocaine.

5. NA acts on alpha and Beta adrnergic receptors.

Beta agonist - salbutamol, salmeterol, formeterol

Beta antagonist - metoprolol, propranolol

Alpha 1 agonist - phenylephrine

Alpha 2 agonist - clonidine