Question

1. If you want a hematopoietic stem cell to develop as a T cell the best approach is to:

a. Have it develop in the bone marrow

b. Make sure it expresses the Notch receptor

c. Have it develop in the spleen

d. Make sure it does NOT express the Notch receptor

2. All of the following with respect to B-cell development in the aging individual are true, EXCEPT:

a. B-cell production swings more to the B-l group

b. Aged bone marrow is not as good as young bone marrow at promoting B-cell development

c. aged individuals do not have enough hematopoietic stem cells left for B-cell development d. Hematopoietic stems cells from the aged do not do as well as young HSCs when transplanted

3. B-cell formation:

a. Initially is mostly B1-B cells, later mostly B2-B cells

b. Is always mostly Bl-B cells

c. Is always mostly B2-B cells

d. Initially is mostly B2-B cells, later mostly Bl-B cells

Answer 1

1. For T cells stand for lymphocytes which mature in the thymus (produced in bone marrow), Notch receptor is required for their differentiation and maturation and in the absent of this receptor they won't bedifferentiated, so the correct option would be b “Make sure it expresses the Notch receptor”

2. Due to ageing aged person will have less efficient B cells and that's why aged people are with compromised immune system, in the given and HSCs loose their function in re-generation or self healing process (self re-newable). That's why bone marrow from aged person is not suitable. Option b, c and d are the correct one, so the wrong statement is a. “B-cell production swings more to the B-l group”

3. B cells are Lymphocytes, which originate and mature in the bone marrow and they are integral part of the humoral immunity. In B cell formation B1 activated after birth and B2 acts on infection of the lymphoid tissue mainly. So correct option would be a. Initially is mostly B1-B cells, later mostly B2-B cells.