Question

All formed elements in blood are derived from hematopoietic stem cells.

1. If an individual lacked hematopoietic growth factors that allowed for the differentiation of myeloid stem cells into megakaryoblasts, what loss of function will that individual experience?
2. Will introduction of thrombopoietin into the system resolve this individual’s condition? Why or why not?

Answer 1

A.

Megakaryocytes are large bone marrow cells which are responsible for the production of blood platelets, which are responsible for normal blood clotting.

megakaryoblasts are precursors of megakaryocyte

Stem cells are converted into Megakaryoblasts by the action of Several Factors like hematopoietic growth factors ( interleukin-3 , granulocyte colony-stimulating factor, erythropoietin etc), thrombopoietin etc

So Due to deficiency of hematopoietic growth factors if stem cells are not converted into megakaryoblasts -----It will lead to reduced production of Platelets---Platelet Deficiency

This will Affect normal Blood CLotting function which will cause excessive bruising, Excessive bleeding from cuts ,reddish-purple spots (petechiae) on the skin etc.

B.

Thrombopoietin is an important regulator of platelet production,which is produced by the liver .

Thrombopoietin Functions-

a.It supports survival of hematopoietic stem cell .

2.Promoting all aspects of development of megakaryocyte .

So the introduction of thrombopoietin into the Patient helps devolopment of Megakaryocytes and platelet production----which can resolve patients condition