Question

4S coronary mortality. The Scandinavian simvastatin survival study (4S) was a randomized clinical trial designed to evaluate the effects of the cholesterol-lowering agent simvastatin in patients with coronary heart disease. Over 5.4 years of follow-up, the treatment group consisting of 2221 individuals experienced 111 fatal heart attacks. The placebo group of 2223 individuals experienced 189 such events. Calculate the risks in the groups and test the difference for significance. In relative terms, how much did simvastatin lower heart attack mortality?

Answer 1

Answer:-

Given That:-

4S coronary mortality. The Scandinavian simvastatin survival study (4S) was a randomized clinical trial designed to evaluate the effects of the cholesterol-lowering agent simvastatin in patients with coronary heart disease. Over 5.4 years of follow-up, the treatment group consisting of 2221 individuals experienced 111 fatal heart attacks. The placebo group of 2223 individuals experienced 189 such events. Calculate the risks in the groups and test the difference for significance. In relative terms,

how much did simvastatin lower heart attack mortality?

Consider the provided details to solve the problem Calculate the incidence proportions as given below.

Test for the proportions .the hypothesis of the test is as follows:

To find the value of Z - statistic:

Now calculate the p - value from the Table F provided in the appendix ,thus ,the two tailed p - value is about 0.0000032 Therefore it is significant to reject the null hypothesis at equal to 0.01 .it is concluded simvastatin group showed lower risk of heart attack then the placebo group.

Determine the risk ratio by using the below given formula

Now, the reduction in risk is observation to be . Therefore ,there is reduction is the risk