During protein synthesis, does translation stop when the signal peptide is synthesized or does translation stop...

During protein synthesis, does translation stop when the signal peptide is synthesized or does translation stop when the SRP (signal receptor particles) bind to the signal peptides -- assuming it's being sent to the endomembrane system?

Expert Solution

Proteins destined for any part of the endomembrane system (or the outside of the cell) are brought to the ER during translation and fed in as they're made.

Signal peptides

The signal peptide that sends a protein into the endoplasmic reticulum during translation and a series of hydrophobic (water-hating) amino acids, basically found near the beginning (N-terminus) of the protein. When this sequence attaches to the ribosome, it’ is recognized by a protein complex called the signal-recognition particle (SRP), which takes the ribosome to the ER. There, the ribosome feeds its amino acid chain into the ER lumen (interior) as it's made.

some times, the signal peptide is cut off during translation of amino acid and the finished protein is released into the interior of the Endoplasmic reticulum. On the other hand, the signal peptide or another stretch of hydrophobic amino acids gets embedded into the endoplasmic reticulum membrane. This creates a transmembrane (membrane-crossing) segment that anchors the protein to the membrane.

refer the picture ..

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gladiator answered 2 years ago

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