True or False - Du positive blood is regarded as Rh-negative for transfusion purposes.

Expert Solution

False. Du positive blood cannot be regarded as Rh-negative (or rather Rh D-negative) for transfusion because it contains a weak form of the D antigen.

Explanation:

A very common antigen type for Rh blood grouping is "D". Thus a person tested as "Rh negative" is actually "Rh D negative" (henceforth mentioned as D-neg), i.e. the person does not have any D antigen on their blood cells. This is determined by rapid clinical tests.

A person with D-neg may donate to both D-positive (D+) and D-neg, but may receive blood only from D-neg. Conversely, a D+ person can donate only to a D+ person. This system of classifying patients as either D-positive or D-negative seemed reliable initially. However, it was later observed that some recipients with D-neg blood showed adverse reactions to blood from D-neg donors. Further investigation revealed that these donors were not actually D-neg, but had Du blood type, i.e. a weak or slow reacting D antigen that could not be detected in rapid clinical tests. Thus, additional tests were required to confirm whether an individual was actually D-neg or simply Du.

Since Du blood contains the D antigen, although in a very weak state, it must not transfused to Rh-negative or rather Rh-D-negative recipients. Thus Du blood cannot be regarded as Rh-negative (or rather Rh D-neg) for transfusion. Conversely, Rh-negative blood can be given to a recipient with blood type Du and D+.

In brief:

Rh-D-negative: can receive Rh-D-negative; can donate to Rh-D-negative, Rh-D-positive, Rh-Du

Rh-D-positive: can receive Rh-D-negative, Rh-D-positive, Rh-Du; can donate to Rh-D-positive, Rh-Du

Rh-Du: can receive from Rh-D-negative, Rh-D-positive, Rh-Du; can donate to Rh-D-positive, Rh-Du

gladiator answered 6 hours ago

what are ABO and Rh blood system? What is a blood transfusion? What is blood typing?...

what are ABO and Rh blood system? What is a blood transfusion? What is blood typing? And What is crossmatch? Why blood typing and crossmatch is important before a patient receiving blood transfusion?

clinical significance of ABO and RH blood group systems in transfusion medicine

Why do mothers that are Rh negative with husbands who are Rh positive must be evaluated...

Why do mothers that are Rh negative with husbands who are Rh positive must be evaluated and immunized many times during pregnancy?

Recent estimates of the distribution of blood types in the U.S. is as follows, where positive and negative refer to the Rhesus (Rh) factor:

Questions 1 - 4 will refer to the following information. Recent estimates of the distribution of blood types in the U.S. is as follows, where positive and negative refer to the Rhesus (Rh) factor: O-positive: 38 %O-negative: 7 %A-positive: 33 %A-negative: 6 %B-positive: 10 %B-negative: 2 %AB-positive: 3 %AB-negative: 1 % 1. What is the probability (expressed as a percentage) that a person randomly selected from the population a) will be Rh-positive? 84 percent probabilityb) will NOT be a universal donor...

After birth, the environment may exert either a positive or negative effect on growth. True False...

After birth, the environment may exert either a positive or negative effect on growth. True False Twins can be labelled as either "monozygotic" (developed from the same egg) or "dyzogotic" (developed from two independent eggs). The difference in height of monozygotic twins is probably caused by environmental factors. True False Body proportions are probably not under genetic control during the growth process. True False

1. A woman is pregnant for the second time. She has Rh negative blood type but...

1. A woman is pregnant for the second time. She has Rh negative blood type but did not receive the RhoGAM shot with her first pregnancy. The baby is born with the following symptoms: enlarged liver and spleen and difficulty breathing. What type of hypersensitivity reaction is this? What is the name of the disease the newborn is experiencing? Can you determine the Rh blood type of the first baby? the second baby? If so,identify the Rh type? 2. A...

The proportion of individuals with an Rh-positive blood type is 84%. You have a random sample...

The proportion of individuals with an Rh-positive blood type is 84%. You have a random sample of n = 500 individuals. (a) What are the mean and standard deviation of p̂, the sample proportion with Rh-positive blood type? (Round your standard deviation to four decimal places.) (b) Is the distribution of p̂ approximately normal? Justify your answer. (c) What is the probability that the sample proportion p̂ exceeds 80%? (Round your answer to four decimal places.) (d) What is the...

describe the context of how a false positive and a false negative fit into the five...

describe the context of how a false positive and a false negative fit into the five steps of systemic toxicological analysis?

What anitsera agglutinates Blood types: A negative, B positive and AB negative?

In the following scenarios identify the Reality, the test, Sensitivity, Specificity, False Negative, and False Positive....

In the following scenarios identify the Reality, the test, Sensitivity, Specificity, False Negative, and False Positive. Then explain which is worse (if either) a False Negative or a False Positive. 1. A Drug Test: a. Reality: b. Test: c. Sensitivity: d. Specificity: e. False Negative: f. False Positive: g. Which is worse:

Question