3. The rate of the citric acid cycle is controlled by— A) a-ketoglutarate dehydrogenase. B) isocitrate...

3. The rate of the citric acid cycle is controlled by—

A) a-ketoglutarate dehydrogenase. B) isocitrate dehydrogenase. C) citrate synthase. D) all of the above. E) none of the above

Solutions

Expert Solution

the answer is D all of the above

all the three enzymes Isocitrate dehydrogenase, α-ketoglutarate dehydrogenase & Citrate synthase are responsble for controlling the rate of citric acid cycle

Citrate synthase catalyses the reaction in which acetyl-CoA is combined with oxaloacetic acid to form citrate. this enzyme is inhibited by high concentration of ATP, acetyl-CoA, and NADH. which indicate high amont of energy being produced and thus rate of cell cycle reduces.Isocitrate dehydrogenase catalyze the oxidative decarboxylation of isocitrate into alpha-ketoglutarate NADH is generated in this process which also acts as inhibitor in large concentration. α-ketoglutarate dehydrogenase catalyses the reaction in which α-ketoglutarate is oxidised reducing NAD+ TO NADH and combining with coenzyme A to form succinyl Co A,both succinyl Co A and NADH act as inhibitors in large concentration.

gladiator answered 1 year ago

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