Explain the effects of each of the following on the rates of gluconeogenesis and/or glycolysis. A....

Explain the effects of each of the following on the rates of gluconeogenesis and/or glycolysis.

A. Increasing the concentration of blood glucose.

B. Increasing the concentration of glucose-6-phosphate.

C. Increasing the concentration of fructose-1,6-bisphosphate.

D. Increasing the levels of ATP.

E. Increasing the concentration of AMP.

F. Decreasing the concentration of fructose-2,6-bisphosphate

G. Increasing the concentration of acetyl CoA

H. Increasing the concentration of citrate.

Solutions

Expert Solution

Consider a net reaction for glycolysis,

glucose + 2NAD + 2ADP + 2Pi ---> 2pyruvates + 2NADH + 2ATP + 2H+ + 2H2O

Similarly we can conclude for glucogenesis also,

So according to LeChatellier's principle, an increase in reactant concentration would shift equilibrium towards right handside (products) and increasing concentration of products would shift equilibrium towards left handside (reactant).

Thus,

A. Increasing the concentration of blood glucose : the rate of gluconeogenesis and/or glycolysis would increase.

B. Increasing the concentration of glucose-6-phosphate : the rate of gluconeogenesis and/or glycolysis would increase.

C. Increasing the concentration of fructose-1,6-bisphosphate : the rate of gluconeogenesis and/or glycolysis would increase.

D. Increasing the levels of ATP : the rate of gluconeogenesis and/or glycolysis would decrease.

E. Increasing the concentration of AMP : the rate of gluconeogenesis and/or glycolysis would increase.

F. Decreasing the concentration of fructose-2,6-bisphosphate : the rate of gluconeogenesis and/or glycolysis would increase.

G. Increasing the concentration of acetyl CoA : the rate of gluconeogenesis and/or glycolysis would decrease.

H. Increasing the concentration of citrate : the rate of gluconeogenesis and/or glycolysis would decrease.

queen_honey_blossom answered 1 year ago

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