How does regulation of glycolysis and gluconeogenesis overlap?

Expert Solution

Mostly F16BP is converted to F6P instead of the reverse reaction. Now there is high amount of F6P which compete with glucose to decide where Hexokinase-regulatory protein complex will be located at cytoplasm (to provide phosphorylation of glucose to G6P) or nucleus (to leave glucose its non-phosphorylated form), at liver. Because in this condition F6P "wins" the race, F6P triggers the movement of complex towards nucleus. Thus now new glucose molecules cannot enter glycolytic pathway. By this mechanism, liver lowers its glucose consumption to preserve glucose reservoir.

queen_honey_blossom answered 1 year ago

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