Question

what are therapeutic action pharmacokinetics contraindications adverse effects and drug-drug interactions and indication of nondepolarizing and depolarization neuromuscular blocker

Answer 1

Neuromuscular blockkers:
Therapeutc action:It works at the neuromuscular junction, it used adjuctively to anesthesia to produce paralysis, the vocal card, permit intubation and cause relaxation of skeletal muscles.
Pharmakokinetics action in class of agent influenced by age or anesthesia agent, it alters the hepatpic or reanl diseases excretion pattern, causes prolong the duration of neuromuscular blockade.
contraindications: when there is a patient with sepsis, burns, massive trauma, CNS infection, prolong bed rest, immobilization, disuse atrophy, peripheral nerve injury, Gillian barrier syndrome cause potential risk, and data condition.
Adverse effects: it causes hypotension, flushing, and tachycardia.
Drug to drug interaction with antimicrobial agents and volatile anesthetic agents affect the sensitivity of the motor and make presynaptic nicotinic function, magnesium inhibits Ach release, procainamide, and quinidine block nicotine receptors channels. calcium antagonists interfere with neuromotor release and muscle contractility. pheytonin and lithium decrease Ach release, corticosteroid, and furosemide increase the transmitter, ecothiopate, tacrine drugs depress cholinesterase activity.
Depolarizing neuromuscular agents depolarize the rapid onset of action, shortest duration of action, used for an emergency situation, and reliable for the incubating condition.
Nondepolarizing agent for short-acting action used to induce anesthesia in intubation, promote skeletal muscle relaxation during surgery and intubation.