Question

What is CYP450 metabolic system? What did you learn about metabolism of drugs and how that impacts you as a nurse in your work and providing the best care possible? You need to also discuss and give examples of what and how a hepatic inducer enzyme (2 examples) and hepatic inhibitor enzyme (2 examples) act in the body and the effects that will likely result.

Answer 1

CYP450 are family of enzymes containing heme that function as monooxygenases.In animals these protein oxidize various components like steroids,fatty acids and xenobiotics,helps in horomone synthesis and breakdown.It is used by the body to metabolize different harmful or toxic products present in drugs or may be synthesized by the own body system.They also help in detoxification of foreign chemicals and metabolism of drugs.In plants it helps in biosynthesis of defensive compounds and hormones.

Metabolism of drugs-It is complete process in which transformation of drugs happen.It is usually to change the chemical structure of the substance,to increase the easy excretion of it from body.Drugs are metabolized by various reactions like oxidation,reduction etc.Metabolism of drug is the process of altering the chemical molecules after entering the body.The metabolism of drug decreases its theraprutic effect.

Understanding of drug metabolism is important for nurse to allow her to better understand the physical and chemical properties of drugs and how they respond with body.

Help the nurse to know about the drug tolerance property of body.

In administration of medicine and in consideration of drug metabolism,nurses also need to understand half life of the drug.

It helps the nurses to understand withdrawal symptoms of a particular drug because of its strength and duration of medication.

Hepatic inducer enzymes: type of drugs which increases the metabolic activity of an enzyme either by binding to enzyme and then activating it or by increasing the expression of gene coding for the enzyme.Drugs which induce hepatic enzymes are called hepatic inducer enzymes.For eg.Rifampicin,anticonvulsants like phenytoin and long term alcohol abuse.

Hepatic inhibitor enzymes:Drugs which inhibit hepatic enzymes by increasing biovailability of other drugs whicg are metabolised by those enzymes or by decreasing the bioavaiability of drugs which require metaboloam for their activation.For eg.Isoniazid,erthromycin

Isoniazid induce a liver enzyme which causes a larger amount of acetaminophen to be metabolized to a toxic form.It decreases the metabolosm of carbamazepine and slows its clearance from the body.

Erythromycin acts by inhibition of protein synthesis by binding 50s ribosomal.It increases hepatic dysfunction.