How is thin layer chromatography technique of separation similar to a paper chromatographic separation?

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	Thin Layer Chromatography	Paper chromatography
Basic application	Thin-layer chromatography (TLC) is a chromatography technique used to separate non-volatile mixtures.	Paper chromatography is an analytical method that is used to separate coloured chemicals or substances.This can also be used in secondary or primary colours in ink experiments. This method has been largely replaced by thin layer chromatography, but is still a powerful teaching tool. It is type of TLC.
Solid support and phases	Thin-layer chromatography is performed on a sheet of glass, plastic, or aluminium foil, which is coated with a thin layer of adsorbent material, usually silica gel, aluminium oxide, or cellulose. This layer of adsorbent is known as the stationary phase.	The stationary phase is usually a piece of high quality filter paper. The mobile phase is a developing solution that travels up the stationary phase, carrying the samples with it. Components of the sample will separate readily according to how strongly they adsorb onto the stationary phase versus how readily they dissolve in the mobile phase.
Principle of working:same	Separation of compounds is based on the competition of the solute and the mobile phase for binding places on the stationary phase.^[3] For instance, if normal-phase silica gel is used as the stationary phase, it can be considered polar. Given two compounds that differ in polarity, the more polar compound has a stronger interaction with the silica and is, therefore, more capable to dispel the mobile phase from the binding places.	Separations in paper chromatography involve the same principles as those in thin layer chromatography, as it is a type of thin layer chromatography.

Both Thin Layer Chromatography and Paper chromatography are used for separation of compounds.

They have certain similarities and differences in between; I tried to make it in tabular format that will be easy for comparison-

queen_honey_blossom answered 1 year ago

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