Question

How does ubiquitination play a role in mitosis?

Answer 1

Ubiquitination:-Attachment of small ubiquitin-protein to last amino acid sequence of the substrate protein is a post-translational modification. The process is highly dynamic and reversible in nature.

In the cell cycle, various transitions are made within a fraction of seconds to precisely divide the genetic material of the cell into 2 daughter cells. The ubiquitination of important mitotic factors increases the fidelity and efficiency of mitosis. Ubiquitination of substrate protein plays an important role in various steps of cell processes like protein degradation, Programme cell death, and quality control,

1. Role of the ubiquitin system in the regulation of mitosis

Ubiquitin system involves the regulation of critical enzymes and factors necessary for the cell cycle

Cell division is controlled by two E3 ligases:- The transition from the G1-S phase is regulated by SCF complexes and the transition from anaphase to mitotic exit is coordinated by APC/C.

2. Role of Deubiquitinating enzymes in mitotic progression

DUBs enzymes are involved in many physiological processes like apoptosis, DNA repair system, Diseases involving neurodegeneration, cancer.

3. Protein degradation in the human cell cycle is monitored by the ubiquitin-proteasome system.