Diuretics
A diuretic is any substance that promotes diuresis, the
increased production of urine.
4 types of
diuretics with use, sideeffects,precaution,
contraindications
| Diuretic | 
Use | 
sideeffects | 
Precautions | 
Contra indications | 
| Thiazide diuretics | 
 • Hypertension 
• Chronic, mild- heart failure 
• Edema 
• Nephrogenic Diabetes insipidus 
• Prevention of Ca++ excretion in osteoporosis and calcium
nephrolithiasis 
 | 
- dizziness
 
- lightheadedness,
 
- blurred vision,
 
- loss of appetite,
 
- itching,
 
- stomach upset,
 
- headache, and
 
- weakness.
 
 
 | 
- renalelectrolyte disturbances
 
- gout,
 
- hyperglycemia,
 
- hypotension
 
 
 | 
- Hypotension.
 
- Allergy to sulfa drugs.
 
- Gout.
 
- Hypokalemia.
 
- Renal failure.
 
- Lithium treatment
 
 
 | 
| Loop diuretics | 
 • Congestive heart failure 
• Acute pulmonary edema 
• Edema due to renal failure, nephrotic syndrome, ascites 
• Hypercalcemia (that induced by malignancy) 
• Severe hypertension 
• Force diuresis during drug/chemical intoxication 
 | 
- hyponatremia
 
- hypokalemia,
 
- hypomagnesemia
 
- dehydration,
 
- hyperuricemia
 
- gout
 
- dizziness,
 
- postural hypotension,
 
- syncope.
 
 
 | 
- Have severe liver or kidney disease
 
- Dehydration
 
- Have an irregular heartbeat
 
- pregnancy and/or have developed high blood pressure during your
pregnancy
 
- age 65 or older
 
- gout
 
- allergic to sulfa drugs, like Septra and Bactrim
(sulfamethoxazole with trimethoprim)
 
 
 | 
- Anuria.
 
- Hypersensitivity to furosemide, bumetanide or torsemide
 
- Hepatic coma.
 
- Severe electrolyte depletion.
 
 
 | 
| oOsmotic diuretics | 
- Removal of nephrotoxic substances
 
- lower intracranial pressure and for short-term reduction of
intraocular pressure.
 
 
 | 
- Extracellular volume expansion
 
- heart failure
 
- pulmonary edema.
 
- Headache
 
- Nausea and vomiting
 
- Dehydration and loss of free water
 
- Hypernatremia or increased sodium levels
 
 
 | 
 Renal or hepatic disease. pregnancy 
lactation 
 | 
- Hepatic disease or insufficiency.
 
- Long-term use in glaucoma.
 
- Hyponatremia, hypokalemia.
 
- Hyperchloremic metabolic acidosis.
 
- Adrenocortical insufficiency.
 
- Severe renal insufficiency.
 
 
 | 
| 
 Potassium-sparing diuretics 
 | 
 heart failure 
Prevent pottasium loss 
Increase the amount of fluid passed from the body in urine 
 | 
- Hyperkalemia
 
- Hyperchloremic metabolic acidosis
 
- Gynecomastia or breast enlargement in males
 
- Erectile dysfunction
 
- Benign prostatic hyperplasia
 
- Acute renal failure
 
- Kidney stones
 
 
 | 
 Pregancy 
Lactation 
Hepatic or renal disorders 
 | 
- Hyponatremia
 
- Hypoklaemia
 
- Adrenocortical insufficiency.
 
- Severe renal insufficiency.
 
- Hepatic disease or insufficiency.
 
- Long-term use in glaucoma.
 
 
 |