Diuretics
A diuretic is any substance that promotes diuresis, the
increased production of urine.
4 types of
diuretics with use, sideeffects,precaution,
contraindications
Diuretic |
Use |
sideeffects |
Precautions |
Contra indications |
Thiazide diuretics |
• Hypertension
• Chronic, mild- heart failure
• Edema
• Nephrogenic Diabetes insipidus
• Prevention of Ca++ excretion in osteoporosis and calcium
nephrolithiasis
|
- dizziness
- lightheadedness,
- blurred vision,
- loss of appetite,
- itching,
- stomach upset,
- headache, and
- weakness.
|
- renalelectrolyte disturbances
- gout,
- hyperglycemia,
- hypotension
|
- Hypotension.
- Allergy to sulfa drugs.
- Gout.
- Hypokalemia.
- Renal failure.
- Lithium treatment
|
Loop diuretics |
• Congestive heart failure
• Acute pulmonary edema
• Edema due to renal failure, nephrotic syndrome, ascites
• Hypercalcemia (that induced by malignancy)
• Severe hypertension
• Force diuresis during drug/chemical intoxication
|
- hyponatremia
- hypokalemia,
- hypomagnesemia
- dehydration,
- hyperuricemia
- gout
- dizziness,
- postural hypotension,
- syncope.
|
- Have severe liver or kidney disease
- Dehydration
- Have an irregular heartbeat
- pregnancy and/or have developed high blood pressure during your
pregnancy
- age 65 or older
- gout
- allergic to sulfa drugs, like Septra and Bactrim
(sulfamethoxazole with trimethoprim)
|
- Anuria.
- Hypersensitivity to furosemide, bumetanide or torsemide
- Hepatic coma.
- Severe electrolyte depletion.
|
oOsmotic diuretics |
- Removal of nephrotoxic substances
- lower intracranial pressure and for short-term reduction of
intraocular pressure.
|
- Extracellular volume expansion
- heart failure
- pulmonary edema.
- Headache
- Nausea and vomiting
- Dehydration and loss of free water
- Hypernatremia or increased sodium levels
|
Renal or hepatic disease. pregnancy
lactation
|
- Hepatic disease or insufficiency.
- Long-term use in glaucoma.
- Hyponatremia, hypokalemia.
- Hyperchloremic metabolic acidosis.
- Adrenocortical insufficiency.
- Severe renal insufficiency.
|
Potassium-sparing diuretics
|
heart failure
Prevent pottasium loss
Increase the amount of fluid passed from the body in urine
|
- Hyperkalemia
- Hyperchloremic metabolic acidosis
- Gynecomastia or breast enlargement in males
- Erectile dysfunction
- Benign prostatic hyperplasia
- Acute renal failure
- Kidney stones
|
Pregancy
Lactation
Hepatic or renal disorders
|
- Hyponatremia
- Hypoklaemia
- Adrenocortical insufficiency.
- Severe renal insufficiency.
- Hepatic disease or insufficiency.
- Long-term use in glaucoma.
|