Different mechanisms create different types of chromosomal aberrations; for example, nondisjunction can cause ____________, while errors...

Different mechanisms create different types of chromosomal aberrations; for example, nondisjunction can cause ____________, while errors in DNA damage repair may cause ____________.

inversions; trisomy

monoploidy; inversions

inversions; monoploidy

trisomy; monoploidy

monoploidy; trisomy

trisomy; inversions

Expert Solution

Different mechanisms create different types of chromosomal aberrations; for example, nondisjunction can cause trisomy, while errors in DNA damage repair may cause inversions.

Trisomy is a condition in which there is a presence of an extra chromosome i.e. the presence of an extra 3rd chromosome instead of a pair of chromosome. Normally there is a pair of each chromosome in a normal cell but in case of trisomy there is an extra chromosome i.e. in case of trisomy-18 there are three chromosome 18 (47, +18). Trisomy occurs due to the non-disjunction of chromosome during meiosis, due to this a chromosome pair fails to separate and the gamete so produce will have an extra chromosome. In case of trisomy-18 it is the presence of an extra 18th-chromosome.

Inversion occur when there is a double strand break in a chromosome at two different positions and then the region between them is inverted and re-joined. If the double strand breaks are repaired correctly by the DNA repair mechanism then inversion might not occur, and the chromosome will be as such. But if there is an error in the DNA damage repair then inversion can occur. It can happen when this kind of breaks are repaired by non-homologous end joining.

gladiator answered 4 months ago

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