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Brain vs. Spinal Cord: A Directed Case Study in CNS Injury By Patrick Field, Department of...

Brain vs. Spinal Cord:

A Directed Case Study in CNS Injury

By

Patrick Field, Department of Biological Sciences, Kean University

Tom Cappaert, Department of Physical Education and Sport, Central Michigan University

Dr. Green and Dr. Carter were nearing the end of the first year of their medical residency in the emergency department of County General Hospital. It had been a long year and a long week. They had been on duty for the last 12 hours and things were not slowing down.

“What are your plans for the weekend, Ken?” Dr. Green asked. “Sleep, what else?” Dr. Carter replied.

“I hope things slow down a bit,” Dr. Green said to himself.

Suddenly, a call came over the radio. Paramedics were bringing in a young man with injuries sustained in a diving accident. A minute later, the doors to the department burst open and the paramedics wheeled in a young man.

“What gives?” Dr. Green asked.

The senior paramedic, Jim Morrison, reported that the patient was swimming at the local quarry and did a forward flip into the water, striking some submerged rocks.

“Which part of his body struck the rocks?” asked Dr. Carter.

“He was in a hyperflexed-tucked-position when he hit the rocks, lacerating the right side of his head and neck and upper back. The patient indicated he had severe pain upon impact and loss of sensation and movement in his arm and leg. He may have lost consciousness, but he’s not sure. He also complains of a severe headache, dizziness, and nausea. When we arrived at the scene we immobilized, stabilized and transported him immediately,” Jim explained.

Looking at the patient, Jim continued. “His name is Mike Smith, and he’s 22 years of age. His vital signs include slightly lowered blood pressure (100/70), heart rate of 75 beats per minute, respiration normal and he is conscious and alert.”

As the patient was being prepped for examination, Dr. Carter and Dr. Green discussed how they should approach their evaluation. Dr. Carter started by saying, “After seeing the head wound and the amount of blood loss, and hearing his complaints, I want to confirm my suspicion that this patient has a brain injury.”

Dr. Green disagreed: “I think that the other signs and symptoms indicate a spinal cord injury, and that’s what we should investigate.”

The following table summarizes the findings of the evaluation, which included a physical exam, x-rays, magnetic resonance imaging (MRI), and neurological tests.

Table 1. Summary of Diagnostic Testing for Mike Smith

Sensory Testing

•Decreased sensation to touch, pressure, and vibration in the right upper/lower extremities

•Decreased temperature discrimination (cold vs. warm) in the left upper/lower extremities

Motor Testing

• Decreased strength and movement of the right upper/lower extremities during muscle testing

• Decreased strength and movement of left abdominal muscles

• Absence of triceps and biceps reflexes in the right upper extremity

• Abnormal response of patellar, Achilles (hyper) reflexes in the right lower extremity

• Positive Babinski sign on the right foot

• Abnormal cremasteric reflex in the right groin region

General Examination

• Abnormal pupil response of right eye (constriction)

• Other vital signs within normal limits

• Cognitive testing normal (counts backward from 100 by 7s; knows name, date, place)

X-Ray and MRI Examination

• No fractures present in the skull

• Fracture in the 7th cervical vertebra

• Significant swelling present in the spinal canal in the C7-T2 region

•Spinal cord appears to be intact

Based upon your previous knowledge of brain function, which results from the testing are consistent with a brain injury and why?


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Match each term to the correct definition or description.

      -       A.       B.       C.       D.       E.       F.       G.       H.       I.       J.       K.       L.       M.       N.       O.   

Efferent neurons

      -       A.       B.       C.       D.       E.       F.       G.       H.       I.       J.       K.       L.       M.       N.       O.   

Sympathetic neurons

      -       A.       B.       C.       D.       E.       F.       G.       H.       I.       J.       K.       L.       M.       N.       O.   

Parasympathetic neurons

      -       A.       B.       C.       D.       E.       F.       G.       H.       I.       J.       K.       L.       M.       N.       O.   

Enteric neurons

      -       A.       B.       C.       D.       E.       F.       G.       H.       I.       J.       K.       L.       M.       N.       O.   

Somatic nervous system

      -       A.       B.       C.       D.       E.       F.       G.       H.       I.       J.       K.       L.       M.       N.       O.   

Neurotransmitters

      -       A.       B.       C.       D.       E.       F.       G.       H.       I.       J.       K.       L.       M.       N.       O.   

Cholinergic

      -       A.       B.       C.       D.       E.       F.       G.       H.       I.       J.       K.       L.       M.       N.       O.   

Adrenergic

      -       A.       B.       C.       D.       E.       F.       G.       H.       I.       J.       K.       L.       M.       N.       O.   

Inhibitory pathways

      -       A.       B.       C.       D.       E.       F.       G.       H.       I.       J.       K.       L.       M.       N.       O.   

Levodopa

      -       A.       B.       C.       D.       E.       F.       G.       H.       I.       J.       K.       L.       M.       N.       O.   

Donepezil

      -       A.       B.       C.       D.       E.       F.       G.       H.       I.       J.       K.       L.       M.       N.       O.   

GABA

      -       A.       B.       C.       D.       E.       F.       G.       H.       I.       J.       K.       L.       M.       N.       O.   

Ramelteon

      -       A.       B.       C.       D.       E.       F.       G.       H.       I.       J.       K.       L.       M.       N.       O.   

Benzodiazepines

      -       A.       B.       C.       D.       E.       F.       G.       H.       I.       J.       K.       L.       M.       N.       O.   

Barbiturates

A.

Selective melatonin receptor agonist

B.

Controlled substances used to sedate patients

C.

Acetylcholinesterase inhibitor used in the treatment of Alzheimer disease

D.

Carry nerve impulses away from the central nervous system to the effector organs

E.

Restores dopaminergic transmission and is used in treatment of Parkinson’s disease

F.

Transmission is mediated by norepinephrine

G.

Collection of nerve fibers that innervate the gastrointestinal tract, pancreas, and gallbladder

H.

Specific chemical signals released from nerve terminals to create communication between nerve cells

I.

Maintain essential bodily functions such as digestion and elimination

J.

Release neurotransmitters GABA or glycine

K.

Transmission is mediated by acetylcholine

L.

Major inhibitory neurotransmitter in the central nervous system

M.

Neurons travel directly to the skeletal muscle and are under voluntary control

N.

Anxiolytic drugs which target GABA receptors

O.

Stimulation creates an increase in heart rate and blood pressure

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