Osteoarthritis (OA)
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Rheumatoid Arthritis (RA)
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Degenerative disease that causes articular cartilage loss and
joint space narrowing.
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Autoimmune disease that causes inflammatory synovitis.
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Heberden's nodes are bony prominences located at the distal
interphalangeal (DIP) joints. Bouchard's nodes are located at the
proximal interphalangeal (PIP) joints.
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Heberden's nodes are absent. Bouchard's nodes are not common,
but may be present.
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Typically affects joint asymmetrically.
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Typically affects joints symmetrically.
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Usually negative/normal lab findings.
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Positive rheumatoid factor, anti-CCP antibody, and elevated ESR
and CRP.
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Radiograph: subchondral sclerosis, osteophytes, cysts, joint
space narrowing, subluxation.
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Radiograph: periarticular osteopenia, bone erosions, joint space
narrowing, subluxation
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the differences between rheumatoid arthritis and
osteoarthritis:
While both rheumatoid arthritis and osteoarthritis
can lead to significant joint destruction and functional
disability, there are many basic differences between these two
forms of arthritis.
Rheumatoid arthritis
- Rheumatoid arthritisis a destructive autoimmune
joint disease that features inflammation in the joint lining tissue
(synovium) that normally produces lubrication and nutrient fluid
for joints. When this tissue remains inflamed, it leads to
deformity (by loosening joint ligaments) and to joint destruction
(by eroding away cartilage and bone).
- Rheumatoid arthritis is an autoimmune disease characterized by
an overactive, misdirected immune system.
- In rheumatoid arthritis, the misdirected immune system attacks
the joint lining tissue leading to destructive inflammation of the
joints. Ligaments, cartilage, and bone can all be damaged from
rheumatoid arthritis.
- Rheumatoid arthritis is also a systemic disease, meaning that
it can additionally involve tissues throughout the body, including
the lungs, skin, and eyes.
- Rheumatoid arthritis tends to affect many joints symmetrically
on both sides of the body.
- The inflammation of active rheumatoid arthritis is
characterized by joint stiffness in the morning lasting over 30
minutes
Osteoarthritis :
- Osteoarthritis is a disease of the cartilage of joints.
- Osteoarthritis is not a systemic disease and not an autoimmune
disease.
- Osteoarthritis is partly a result of natural aging of the
joint. With aging, the water content of the cartilage increases,
and the protein makeup of cartilage degenerates as a function of
biologic processes. Eventually, cartilage begins to degenerate by
flaking or forming tiny crevasses.
- In advanced osteoarthritis, there is a total loss of the
cartilage cushion between the bones of the joints.
- Repetitive use of the worn joints over the years can
mechanically irritate and inflame the cartilage, causing
joint pain and swelling.
- Loss of the cartilage cushion causes friction between the
bones, leading to pain and limitation of joint mobility.
- Inflammation of the cartilage can also stimulate new bone
outgrowths (spurs, also referred to as osteophytes) to form around
the joints.
- Osteoarthritis occasionally can develop in multiple members of
the same family, implying a hereditary (genetic) basis for this
condition.
- Osteoarthritis is, therefore, felt to be a result of a
combination of each of the above factors that ultimately lead to a
narrowing of the cartilage in the affected joint.
- Osteoarthritis is sometimes referred to as degenerative joint
disease.