Question

Certain antibody isotypes are more important from blood-borne infections while other isotypes are more important for food-borne infections. Taking this into consideration, draw two different immunoglobulin with different effector functions, present in two different tissues of the body. Your drawing should demonstrate the effect the specific antibody isotype has within the tissue.

Include:

1) labels to indicate the isotype of the antibody you have drawn

2) labels to indicate the receptor that recognizes the antibody, the cell with the receptor, the tissue which the cell is located in, an antigen binding to the antibody, and the effect the antibody performs.

3) add a sentence or two to describe what happens to a person lacking the certain receptor or antibody you have described in each drawing.

Answer 1

1.There are 5 immunoglobulin classes (isotopes ) such

IgG, IgM, IgA, IgE and IgD

Receptors of IgG are FC-gamma receptors.

Receptors of IgA are FC-alpha receptors.

Receptors of IgE are FC-epsilon receptors.

cells in which IgG, IgA or IgM will be in the lymphoid cell which is located in small intestine, lungs and lymphoid organs.

Antigen -Antibody interaction :It is a specific chemical interaction between antibodies produced by b cells of white blood cells and antigens diring immune reaction. The antigen -antibody combines by a process called agglutination.It is a fundamental reaction in the body by which body is protected by complex foreign molecules such as pathogens and chemical toxics.

Effects of antibody performs:Antibodies are produced by plasma cells, but, once secreted, can act independently against extracellular pathogens and toxics.

2.Deficiency of this immunoglobulin :sinus infection and other respiratory infection, gastro intestinal infection, ear infection, pneumonia, bronchitis.