Draw and describe in detail how LDL enters a cell and is eventually broken down into...

Draw and describe in detail how LDL enters a cell and is eventually broken down into free cholesterol molecules.

Expert Solution

LDL containing cholesteryl ester binds via ApoB protein to LDL receptor on clathrin-coated pit. These pits are then bud into clathrin-coated vesicle engulfing LDL particle into the cell. Upon entering the cytosol, this clathrin-coated vesicle binds to endosome releasing the clathrin triskelions. This endosome has the pH of approximately 5 which releases LDL receptors as a membrane-bound body. This LDL receptor is then recycled at the plasma membrane. The endosome is then joined by lysosome forming lysoendosome which cleaves the LDL into raw materials like amino acids of ApoB protein and fatty acids and free cholesterol into the cytosol. This cholesterol is stored as droplets inside the endoplasmic reticulum.

gladiator answered 2 years ago

When glucose enters a pancreatic beta cell, it is broken down and triggers a cascade of...

When glucose enters a pancreatic beta cell, it is broken down and triggers a cascade of events leading to insulin production and secretion. Describe the steps involved. Bullet points with no description will only receive partial grade.

Describe how the fats are broken down from the fat globules to chylomicrons in the small...

Describe how the fats are broken down from the fat globules to chylomicrons in the small intestine. Be sure to name them at every step.

describe Impact of Eradicating Smallpox For the case study analysis is to be broken down into...

describe Impact of Eradicating Smallpox For the case study analysis is to be broken down into the following steps. How is the Public Health Department integrated with the CDC and the FDA? Identify the most important facts surrounding the case. Identify the key issue or issues. What the results and findings of the investigation. Specify alternative courses of action

Describe in detail how naive B lymphocytes become a plasma cell

How are the molecules of a saltine cracker (they contain amylose and amylopectin) broken down and...

How are the molecules of a saltine cracker (they contain amylose and amylopectin) broken down and absorbed into your body? Once they are absorbed, how are these energetic molecules stored until the body needs energy? How are these storage molecules broken down by cells so that they can be utilized by the organism? What hormone molecule regulates the levels of glucagons in the blood, and how do they do this? What diseases result when these hormone molecules stop functioning and...

• What are variable costs? How are they broken down? • Explain the concept of payback...

• What are variable costs? How are they broken down? • Explain the concept of payback period. • Discuss the concept of fixed costs. How are they different from variable costs? • Give three reasons to keep good records every day.

Briefly describe how DNA is packaged to fit inside a cell. Explain, in detail, how DNA...

Briefly describe how DNA is packaged to fit inside a cell. Explain, in detail, how DNA replication occurs. INCLUDE: DNA polymerase, RNA polymerase, primase and ligase. 500 words minimum

1. Answer the following completely and in detail. a) Draw, clearly label, and describe how binding...

1. Answer the following completely and in detail. a) Draw, clearly label, and describe how binding of the trp corepressor to its repressor alters repressor function and transcription in E. coli. b) Draw, clearly label, and describe the binding of RNA polymerase, repressors, and activators to the lac operon when both lactose and glucose are scarce. What is the effect of these scarcities on transcription of the lac operon? c) Suppose that a certain mutation in E. coli changes the...

Question: How does poliovirus replicate in the epithelial cell of intestine? Describe in detail, not only...

Question: How does poliovirus replicate in the epithelial cell of intestine? Describe in detail, not only main idea.

How is the total variation in the dependent variable broken down in analysis of variance? 2....

How is the total variation in the dependent variable broken down in analysis of variance? 2. What does the total sum of squares describe? What are its degrees of freedom? 3. What is the mathematical expression for the sum of squares for treatments? 4. What is the grand mean? How is it calculated? 5. What is the mean square for treatments? 6. What is the relationship between TSS, SST, and SSE? Explain why this relationship makes sense..

Question